Format:
Online-Ressource
ISSN:
1521-4141
Content:
Abstract: The non‐obese diabetic (NOD) mouse is an established animal model of the autoimmune disease, insulin‐dependent diabetes mellitus (IDDM). The NOD‐E mouse is a transgenic mouse which expresses the I‐E molecule (absent in NOD mice). Expression of I‐E protects these mice from both insulitis and IDDM.We have investigated the possible mechanisms of this protection by constructing bone marrow, and combined bone marrow and thymus chimeras between NOD and NOD‐E mice. Our data suggest that thymic epithelium may play no direct role in either protection against, or promotion of, IDDM. Protection from diabetes is provided either by NOD‐E donor bone marrow or NOD‐E recipient non‐thymic radioresistant cells. The means by which protection may be achieved in this system are discussed.
In:
volume:23
In:
number:10
In:
year:2005
In:
pages:2667-2675
In:
extent:9
In:
European journal of immunology, Weinheim : Wiley-VCH, 1971-, 23, Heft 10 (2005), 2667-2675 (gesamt 9), 1521-4141
Language:
English
DOI:
10.1002/eji.1830231042
URN:
urn:nbn:de:101:1-2024012904283967565529
URL:
https://doi.org/10.1002/eji.1830231042
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2024012904283967565529
URL:
https://d-nb.info/1317458354/34
URL:
https://doi.org/10.1002/eji.1830231042
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