In:
Ministry of Science and Technology, Vietnam, Ministry of Science and Technology, Vietnam (VMOST), Vol. 64, No. 2 ( 2022-2-25), p. 1-4
Abstract:
This research aimed to investigate the correlation between genotype of single nucleotide polymorphisms MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRRA66G and recurrent pregnancy loss (RPL). A case-control study was performed on 92 women suffering from URPL and 92 women who had a normal history of pregnancy. Regarding MTHFR C677T, the average numbers of alleles, heterozygous genotypes, and mutant homozygous genotypes were significantly higher in the group with RPL (p 〈 0.05), women with these genotypes had a greater incidence of having recurrent pregnancy losses 2.5 fold (OR 2.5, 95% CI, 1.27-4.94, p=0.0041), and 4.57 fold (OR 4.57, 95% CI, 1.05-27.41, p=0.0190), separately. Otherwise, the cases were also significantly higher in MTR A2756G mutant allele versus the controls (p 〈 0.05). However, in terms of the MTHFR A1298C, MTR A2756G, MTRRA66G polymorphisms, the obtained results were similar and they were not risks factor of recurrent pregnancy loss (p 〉 0.05). The polymorphism MTHFR C677T is a risk factor for the RPL in the participants. Regarding the MTHFR A1298C, MTR A2756G, and MTRR A66G polymorphisms, more research has to be done to further analyse their correlation.
Type of Medium:
Online Resource
ISSN:
1859-4794
DOI:
10.31276/VJST.vol(number).page
DOI:
10.31276/VJST.64(2).01-04
Language:
Unknown
Publisher:
Ministry of Science and Technology, Vietnam (VMOST)
Publication Date:
2022
SSG:
6,25
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