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  • 1
    UID:
    (DE-627)1588204693
    Format: 13
    ISSN: 2041-4889
    Content: Alpha-fetoprotein (AFP) has been recognized as a key regulator of cell proliferation in hepatocellular carcinoma (HCC). However, whether AFP functions in cancer cell autophagy remains unknown. This study investigated the effects of AFP on autophagy in HCC cells. The role of AFP was studied in two HCC cell lines, PLC/PRF/5 and HLE. Cell autophagy, apoptosis, proliferation, migration and invasion were analysed with Western blotting, co-immunoprecipitation (CoIP), immunofluorescence, animal models, MTT assays, flow cytometry (FCM), Cell Counting Kit (CCK)-8, and scratch and transwell assays. In PLC/PRF/5 cells, AFP interacted with PTEN and activated PI3K/Akt/mTOR signalling. In HLE cells, overexpressed AFP similarly interacted with PTEN, leading to PI3K/Akt/mTOR activation and reduced cell autophagy. When AFP was silenced in PLC/PRF/5 cells, cell proliferation, tumour growth, migration and invasion were inhibited, and the numbers of S-phase and apoptotic cells were increased. In contrast, AFP overexpression in HLE cells enhanced cell proliferation, migration and invasion and reduced apoptosis. AFP-dependent autophagy, proliferation, migration and apoptosis were inhibited by rapamycin. In summary, AFP plays critical roles in the inhibition of autophagy and apoptosis in HCC cells and promotes proliferation, migration and invasion. The role of AFP in autophagy inhibition in HCC cells may involve the activation of PI3K/Akt/mTOR signalling.
    Note: Gesehen am 28.02.2019
    In: Cell death & disease, London [u.a.] : Nature Publishing Group, 2010, 9(2018) Artikel-Nummer 1027, 13 Seiten, 2041-4889
    In: volume:9
    In: year:2018
    In: extent:13
    Language: English
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  • 2
    UID:
    (DE-627)1618799614
    Format: x, 296 Seiten , Illustrationen
    ISBN: 9789401780438
    Series Statement: Intelligent systems, control and automation: science and engineering volume 72
    Additional Edition: 9789401780445
    Additional Edition: Erscheint auch als Onlineausg. Xu, Honglei Optimization and Control Methods in Industrial Engineering and Construction Dordrecht : Springer Netherlands, 2014 9789401780445
    Language: English
    Keywords: Industrie ; Produktion ; Regelungstechnik ; Steuerung ; Projektmanagement ; Optimierung ; Robuste Regelung ; Optimalwertregelung ; Transporttheorie ; Operations Research ; Industrie ; Produktion ; Regelungstechnik ; Steuerung ; Projektmanagement ; Optimierung ; Robuste Regelung ; Optimalwertregelung ; Transporttheorie ; Operations Research ; Aufsatzsammlung
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  • 3
    UID:
    (DE-627)1588205215
    Format: 1
    ISSN: 2041-4889
    Content: The correct ordering and designations for corresponding/first authors are as follows: Shanshan Wang1,2*, Mingyue Zhu3, Qiaoyun Wang3, Yuli Hou4, Lei Li5, Honglei Weng6, Yan Zhao4, Dexi Chen1,2, Junli Guo3, Huiguo Ding#5, Mengsen Li#3
    Note: Gesehen am 28.02.2019
    In: Cell death & disease, London [u.a.] : Nature Publishing Group, 2010, 10(2019,2) Artikel-Nummer 83, 1 Seite, 2041-4889
    In: volume:10
    In: year:2019
    In: number:2
    In: extent:1
    Language: English
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  • 4
    Online Resource
    Online Resource
    Dordrecht : Springer Netherlands
    UID:
    (DE-627)165321113X
    Format: Online-Ressource (X, 296 p. 63 illus., 39 illus. in color, online resource)
    ISBN: 9789401780445
    Series Statement: Intelligent Systems, Control and Automation: Science and Engineering 72
    Content: This book presents recent advances in optimization and control methods with applications to industrial engineering and construction management. It consists of 15 chapters authored by recognized experts in a variety of fields including control and operation research, industrial engineering, and project management. Topics include numerical methods in unconstrained optimization, robust optimal control problems, set splitting problems, optimum confidence interval analysis, a monitoring networks optimization survey, distributed fault detection, nonferrous industrial optimization approaches, neural networks in traffic flows, economic scheduling of CCHP systems, a project scheduling optimization survey, lean and agile construction project management, practical construction projects in Hong Kong, dynamic project management, production control in PC4P, and target contracts optimization. The book offers a valuable reference work for scientists, engineers, researchers and practitioners in industrial engineering and construction management
    Note: Description based upon print version of record , PrefaceRobustness of Convergence Proofs in Numerical Methods in Unconstrained Optimization -- Robust Optimal Control of Continuous Linear Quadratic System Subject to Disturbances -- A Linearly-Growing Conversion from the Set Splitting Problem to the Directed Hamiltonian Cycle Problem -- Optimum Confidence Interval Analysis in Two-factor Mixed Model with a Concomitant Variable for Gauge Study -- Optimization of Engineering Survey Monitoring Networks -- Distributed Fault Detection Using Consensus of Markov Chains -- Engineering Optimization Approaches of Nonferrous Metallurgical Processes -- Development of Neural Network Based Traffic Flow Predictors Using Pre-Processed Data -- Economic Scheduling of CCHP Systems Considering the Tradable Green Certificates -- Optimizations in Project Scheduling: A State-of-Art Survey -- Lean and Agile Construction Project Management: as a Way of Reducing Environmental Footprint of the Construction Industry -- Managing Construction Projects in Hong Kong: Analysis of Dynamic Implications of Industrial Improvement Strategies -- Dynamic Project Management: an Application of System Dynamics in Construction Engineering and Management. A Lean Framework for Production Control in Complex and Constrained Construction Projects (PC4P) Optimization in the Development of Target Contracts.
    Additional Edition: 9789401780438
    Additional Edition: Druckausg. Optimization and control methods in industrial engineering and construction Dordrecht : Springer, 2014 9789401780438
    Language: English
    Keywords: Industrie ; Produktion ; Regelungstechnik ; Steuerung ; Projektmanagement ; Optimierung ; Robuste Regelung ; Optimalwertregelung ; Transporttheorie ; Operations Research ; Industrie ; Produktion ; Regelungstechnik ; Steuerung ; Projektmanagement ; Optimierung ; Robuste Regelung ; Optimalwertregelung ; Transporttheorie ; Operations Research
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 5
    Online Resource
    Online Resource
    Dordrecht : Springer Netherlands | Cham : Springer International Publishing AG
    UID:
    (DE-603)336006888
    Format: 1 Online-Ressource (X, 296 Seiten) , 63 illus., 39 illus. in color.
    Edition: 1st ed. 2014
    ISBN: 9789401780445 , 9401780447
    Series Statement: Intelligent Systems, Control and Automation: Science and Engineering 72
    Additional Edition: Erscheint auch als Druck-Ausgabe Optimization and Control Methods in Industrial Engineering and Construction Dordrecht : Springer Netherlands, 2014 9789401780438
    Additional Edition: 9789401780438
    Additional Edition: 9789401780452
    Additional Edition: 9789402401707
    Language: English
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  • 6
    UID:
    (DE-605)TT050426105
    Format: X, 296 p. 63 illus., 39 illus. in color
    ISBN: 9789401780445
    Series Statement: Intelligent Systems, Control and Automation: Science and Engineering 72
    Additional Edition: Erscheint auch als Druck-Ausgabe 9789401780438
    Language: English
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  • 7
    UID:
    (DE-627)1746207663
    Format: 1 online resource (300 pages)
    Edition: 1st ed.
    ISBN: 9789401780445
    Series Statement: Intelligent Systems, Control and Automation: Science and Engineering Ser. v.72
    Content: Surveying advances in optimization and control methods with applications to industrial engineering and construction management, this book covers lean and agile construction project management, set splitting problems, distributed fault detection and more.
    Content: Intro -- Preface -- Contents -- 1 Robustness of Convergence Proofs in Numerical Methods in Unconstrained Optimization -- 1 Introduction -- 2 Convergence Proof by Using Lyapunov Function Theorem in Optimization -- 3 Zoutendijk Convergence Analysis of a Numerical Method in Optimization -- 4 Analysis of a Counterexample Without Properly Nested Level Sets -- 5 Conclusion -- References -- 2 Robust Optimal Control of Continuous Linear Quadratic System Subject to Disturbances -- 1 Introduction -- 2 Problem Formulation -- 3 Existence Theorem -- 4 Problem Approximation -- 5 Sub-problem Solution -- 6 Numerical Experiment -- 7 Concluding Remarks and Future Research -- References -- 3 A Linearly-Growing Conversion from the Set Splitting Problem to the Directed Hamiltonian Cycle Problem -- 1 Introduction -- 2 Simplifying the SSP Instance -- 3 Algorithm for Converting an SSP Instance to an Instance of Directed HCP -- 4 The Intended Interpretation of the Converted Graph -- 5 Proof of Conversion -- 6 Examples -- References -- 4 Optimum Confidence Interval Analysis in Two-Factor Mixed Model with a Concomitant Variable for Gauge Study -- 1 Introduction -- 1.1 Gauge Study -- 1.2 Literature Review -- 2 Model Description -- 2.1 Confidence Interval Approach -- 2.2 A Two-Factor Mixed Model with a Concomitant Variable and No Interaction -- 2.3 ANOVA Tables of the Model -- 3 Statistical Distributions of Sums of Squares -- 3.1 Theorems of Chi-Squared Distributions -- 3.2 Theorem of Independency of Chi-Squared Distributions -- 4 Confidence Intervals on Variability -- 4.1 MLS Intervals on Variance Components -- 4.2 Generalized Intervals on Variance Components -- 5 Numerical Example -- References -- 5 Optimization of Engineering Survey Monitoring Networks -- 1 Introduction -- 2 Overcoming Rank Deficiency: Use of Exterior Constraints -- 2.1 Direct Substitution.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9789401780438
    Additional Edition: Erscheint auch als Druck-Ausgabe 9789401780438
    Language: English
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  • 8
    Book
    Book
    San Rafael : Morgan & Claypool Life Science Publishers
    UID:
    (DE-602)b3kat_BV047122183
    Format: x, 43 Seiten , Illustrationen
    ISBN: 9781615047994 , 9781615047970
    Series Statement: Colloquium Series on Neuroglia in Biology and Medicine: from Physiology to Disease # 12
    Note: Part of: Colloquium digital library of life sciences
    Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-1-61504-798-7
    Language: English
    Subjects: Biology
    RVK:
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  • 9
    Online Resource
    Online Resource
    Basel : MDPI
    UID:
    (DE-602)b3kat_BV049048260
    Format: 1 Online-Ressource (vii, 505 Seiten)
    ISBN: 9783036566047
    Note: Printed edition of the special issue published in "Atmosphere"
    Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-0365-6605-4
    Language: English
    Subjects: Geography
    RVK:
    Keywords: China ; Luftverschmutzung
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
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  • 10
    UID:
    (DE-605)HT030376545
    Format: 1 electronic resource (516 pages)
    ISBN: 9783036566047
    Note: English
    Language: English
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