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  • 1
    Online Resource
    Online Resource
    The comet assay in toxicology (2009)
    Cambridge : Royal Society of Chemistry
    Details
    UID:
    b3kat_BV037195527
    Format: 1 Online-Ressource (374 p.) , 43 b&w, ill
    ISBN: 1847559743 , 9781847559746
    Series Statement: Issues in toxicology v. 5
    Note: The first book of its kind, devoted exclusively to the assessment of DNA damage by the Comet assay in modern toxicology, The vast number of chemicals existing or being added into the environment, have globally aroused great concern regarding their adverse effects in human population. Development and validation of sensitive and better test systems which can assess the adverse effects of chemicals at an early stage for intervention strategies to be implemented in time is currently in progress. This book documents the latest research and showcases the versatile, state-of-the-art technique - the Comet assay - in the field of modern toxicology. The assay is a simple, sensitive rapid and visual technique for the quantitative and qualitative assessment of DNA damage in single cells. The Comet Assay in Toxicology is the first book of its kind to be devoted exclusively to the Comet assay and its applications as an important tool in modern toxicology. This multi-author book will serve as both a reference and a guide to investigations in the biomedical, biochemical and pharmaceutical sciences. Written by investigators from the fields of genetic toxicology and human epidemiology, the authors have first-hand knowledge from their chosen sub-specialities and are active contributors to the peer-reviewed scientific literature. The book is divided into five major sections, reflecting the range of interest in the exploitation of this assay. The book's scope begins with an introduction section reviewing its genesis for those new to the technique and the current knowledge of the various fields in which it finds wide acceptance. This section sets the scene by explaining why the assay has become the most sensitive and sought after assay in modern toxicology. Next is a whole section that considers various procedures being followed to assess different types of DNA damage in various cell t++ , ypes and is contributed by experts in the respective fields. The third section puts together the specific applications of the assay in the diverse fields ranging from genetic toxicity testing to human monitoring, and environmental toxicology. The fourth section consists of the guidelines and recommendations for the conduct of the assay in in vitro and in vivo systems, based on the recommendations of the International Workgroups on genotoxicity test procedures. Finally, the book draws to a close with an assessment of the statistics used for the understanding of the data generated by the assay. This is a unique reference book as it provides the scientific community with the advances in Comet assay as well as its applications. It also incorporates a detailed section with instant and comprehensive information on the procedure of the assay and the latest protocols being used worldwide as well as statistical analyses to be followed. The book is aimed at students as well as scientists in the area of molecular epidemiology and genetic toxicology
    Language: English
    Subjects: Chemistry/Pharmacy
    RVK:
    VT 5300
    URL: Volltext
    URL: Volltext  (Deutschlandweit zugänglich)
    URL: Volltext  (Deutschlandweit zugänglich)
    URL: Volltext
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    Stabi Berlin
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    UB Potsdam
    TH Wildau
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  • 2
    Online Resource
    Online Resource
    Translational Toxicology : Defining a New Therapeutic Discipline (2016)
    Cham : Springer International Publishing
    Details
    UID:
    b3kat_BV043547075
    Format: 1 Online-Ressource (XV, 380 p. 32 illus., 12 illus. in color)
    Edition: 1st ed. 2016
    ISBN: 9783319274492
    Series Statement: Molecular and Integrative Toxicology
    Additional Edition: Erscheint auch als Druckausgabe ISBN 978-3-319-27447-8
    Language: English
    DOI: 10.1007/978-3-319-27449-2
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: Inhaltsverzeichnis
    URL: Abstract
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    HTW Berlin
    BTU Cottbus
  • 3
    Book
    Book
    Genetic toxicology of complex mixtures (1990)
    New York [u.a.] : Plenum Press
    Details
    UID:
    b3kat_BV004475528
    Format: IX, 375 S.
    ISBN: 0306436833
    Series Statement: Environmental science research 39
    Language: English
    Subjects: Biology , Medicine
    RVK:
    WG 3230
    RVK:
    XH 4819
    Keywords: Umweltmutagen ; Toxizitätstest ; Umweltchemikalie ; Mutagenität ; Umweltmutagen ; Chemische Analyse ; Umweltmutagen ; Carcinogen ; Konferenzschrift ; Konferenzschrift ; Konferenzschrift
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  • 4
    Online Resource
    Online Resource
    Translational toxicology and therapeutics : windows of developmental susceptibility in reproduction and cancer (2018)
    Hoboken, NJ :Wiley,
    Details
    UID:
    almafu_9959328207102883
    Format: 1 online resource
    ISBN: 9781119023623 , 1119023629 , 9781119023647 , 1119023645
    Content: "this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. •Provides information on lifestyle choices that can reduce cancer risk •Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants •Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health •Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms" -- from website publisher
    Note: Introduction: The Case for Concern about Mutation and Cancer Susceptibility during Critical Windows of Development and the Opportunity to Translate Toxicology into a Therapeutic Discipline. What Stressors Cause Cancer and When? / Claude L Hughes, Michael D Waters -- What Mutagenic Events Contribute to Human Cancer and Genetic Disease? / Michael D Waters -- Developmental Origins of Cancer / Suryanarayana V Vulimiri, John M Rogers -- The Mechanistic Basis of Cancer Prevention / Bernard W Stewart -- Exposures that Could Alter the Risk of Cancer Occurrence, and Impact Its Indolent or Aggressive Behavior and Progression Over Time. Diet Factors in Cancer Risk / Lynnette R Ferguson -- Voluntary Exposures: Natural Herbals, Supplements, and Substances of Abuse -- What Evidence Distinguishes Therapeutic from Adverse Responses? / Eli P Crapper, Kylie Wasser, Katelyn J Foster, Warren G Foster -- Voluntary Exposures: Pharmaceutical Chemicals in Prescription and Over-the-Counter Drugs -- Passing the Testing Gauntlet / Ronald D Snyder -- Children's and Adult Involuntary and Occupational Exposures and Cancer / Annamaria Colacci, Monica Vaccari -- Gene-Environment Interactions. Ethnicity, Geographic Location, and Cancer / Fengyu Zhang -- Dietary/Supplemental Interventions and Personal Dietary Preferences for Cancer: Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction / Sandeep Kaur, Elaine Trujillo, Harold Seifried -- Social Determinants of Health and the Environmental Exposures: A Promising Partnership / Lauren Fordyce, David Berrigan, Shobha Srinivasan -- Categorical and Pleiotropic Nonmutagenic Modes of Action of Toxicants: Causality. Bisphenol A and Nongenotoxic Drivers of Cancer / Natalie R Gassman, Samuel H Wilson -- Toxicoepigenetics and Effects on Life Course Disease Susceptibility / Luke Montrose, Jaclyn M Goodrich, Dana C Dolinoy -- Tumor-Promoting/Associated Inflammation and the Microenvironment: A State of the Science and New Horizons / William H Bisson, Amedeo Amedei, Lorenzo Memeo, Stefano Forte, Dean W Felsher -- Metabolic Dysregulation in Environmental Carcinogenesis and Toxicology / R Brooks Robey -- Biomarkers for Detecting Premalignant Effects and Responses to Protective Therapies during Critical Windows of Development. Circulating Molecular and Cellular Biomarkers in Cancer / Ilaria Chiodi, A Ivana Scovassi, Chiara Mondello -- Global Profiling Platforms and Data Integration to Inform Systems Biology and Translational Toxicology / Barbara A Wetmore -- Developing a Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction / Rebecca Johnson, David Kerr -- Ethical Considerations in Developing Strategies for Protecting Fetuses, Neonates, Children, and Adolescents from Exposures to Hazardous Environmental Agents / David B Resnik, Melissa J Mills.
    Language: English
    Keywords: Electronic books. ; Electronic books. ; Electronic books.
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119023647
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119023647
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119023647
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    HU Berlin
    FU Berlin
  • 5
    Online Resource
    Online Resource
    Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures (1979)
    Boston, MA : Springer US
    Details
    UID:
    b3kat_BV042411984
    Format: 1 Online-Ressource (XIII, 588 p)
    ISBN: 9781468436112 , 9781468436136
    Series Statement: Environmental Science Research 15
    Note: vi Williamsburg, Virginia, February 21-23, 1978. This symposium was sponsored by the U. S. Environmental Protection Agency, Office of Energy Minerals and Industry, Washington, DC, and Office of Health and Ecological Effects, Health Effects Research Laboratory, Biochemistry Branch, Research Triangle Park, NC. The symposium consisted of 24 formal presentations that amplify the three major topics discussed during the symposium: an overview of short-term bioassay systems; current methodology involving the collection and chemical analysis of environmental samples; and current research involving the use of short-term bioassays in the fractionation and analysis of complex environmental mixtures. The purpose of this symposium was to present the state-of-the-art techniques in bioassay and chemical analysis as applied to complex mixtures and to foster continued advancement of this important area. Complex mixtures discussed include ambient air and water, waste water, drinking water, shale oil, synthetic fuels, automobile exhaust, diesel particulate, coal fly ash, cigarette smoke condensates, and food products. It is our hope that this volume will serve as a reference to catalyze and encourage further research in this field. Michael D. Waters, Ph. D. Stephen Nesnow, Ph. D. vii Acknowledgment We would like to thank Gerald Rausa, Office of Energy Minerals and Industry, for his advice, encouragement, and support of this program. We would also like to express our appreciation to Wendy A. Martin, Peter A. Murphy, and David F. Wright of Kappa Systems, Inc
    Language: English
    Keywords: Konferenzschrift
    DOI: 10.1007/978-1-4684-3611-2
    URL: Volltext
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  • 6
    Online Resource
    Online Resource
    Genetic Toxicology of Complex Mixtures (1990)
    Boston, MA : Springer US
    Details
    UID:
    b3kat_BV042412093
    Format: 1 Online-Ressource (384p)
    ISBN: 9781468458503 , 9781468458527
    Series Statement: Environmental Science Research 39
    Note: Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source characterization and source apportionment were discussed as an aid to understanding the origin and relative contribution of various kinds of complex mixtures to the ambient environment. Similarly, investigations of genotoxicants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose­to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects
    Language: English
    Keywords: Umweltchemikalie ; Mutagenität ; Umweltmutagen ; Chemische Analyse ; Umweltmutagen ; Toxizitätstest ; Carcinogen ; Konferenzschrift
    DOI: 10.1007/978-1-4684-5850-3
    URL: Volltext
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  • 7
    Book
    Book
    Short- term bioassays in the analysis of complex environmental mixtures II : [proceedings of the 2. Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures, held in Williamsburg, Va., March 4-7, 1980] (1981)
    New York [u.a.] : Plenum Pr.
    Details
    UID:
    gbv_441302513
    Format: XV, 524 S. : graph. Darst. ; 26 cm
    Series Statement: (Environmental science research 22)
    Note: Forts. zu: Application of short- term bioassays in the fractionation and analysis of complex environmental mixtures , Literaturangaben
    Language: Undetermined
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  • 8
    Book
    Book
    Application of short- term bioassays in the fractionation and analysis of complex environmental mixtures : [proceedings of the Symposium on Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures, held at Williamsburg, Va., Febr. 21-23, 1978] (1979)
    New York [u.a.] : Plenum Pr.
    Details
    UID:
    gbv_43497854X
    Format: XIII, 588 S. : Ill., graph. Darst. ; 26 cm
    Series Statement: (Environmental science research 15)
    Note: Literaturangaben
    Language: Undetermined
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  • 9
    Online Resource
    Online Resource
    Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III (1983)
    Boston, MA : Springer US
    Details
    UID:
    b3kat_BV042411428
    Format: 1 Online-Ressource (589p)
    ISBN: 9781461336112 , 9781461336136
    Series Statement: Environmental Science Research 27
    Note: In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short­ term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate
    Language: English
    DOI: 10.1007/978-1-4613-3611-2
    URL: Volltext
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  • 10
    Online Resource
    Online Resource
    Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV (1985)
    Boston, MA : Springer US
    Details
    UID:
    b3kat_BV042411730
    Format: 1 Online-Ressource (384p)
    ISBN: 9781461578499 , 9781461578512
    Series Statement: Environmental Science Research 32
    Note: With this proceedings of the fourth symposium on complex mixtures, we continue to revise and extend our knowledge of genetic methods for the evaluation of chemical mixtures in the environment. The early chapters of this volume are devoted to new bioassay techniques that are directly applicable to the monitoring of environments contaminated with genotoxic chemicals. Microbiological methods have been further refined to meet the special needs of atmospheric monitoring so that very small samples may now be efficiently tested. New in situ methods utilizing green plants actually avoid many of the usual difficulties of sample collection and preparation and offer special advantages in monitoring wastewater, sludges, and hazardous wastes. Insects also are being employed very effectively in the evaluation of gaseous air pollutants in controlled laboratory investigations. Increased emphasis has been placed on a comprehensive assessment of the potential of complex mixtures t9 cause various kinds of genetic damage. New assays for chromosome structural and numerical aberrations in mammalian cells in vitro have been developed and are being applied in laboratory studies. Efforts to link tests for gene mutation and cell transformation in vitro with assays for tumorigenesis in vivo are contributing to the validation of the short-term testing approach. Studies comparing in vitro and in vivo data on a coal conversion by-product, on polycyclic aromatic hydrocarbons, and on mineral fibers are reported in separate papers. Later chapters are devoted to investigations on the fractionation and biological evaluation of specific chemical components within complex mixtures
    Language: English
    DOI: 10.1007/978-1-4615-7849-9
    URL: Volltext
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