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  • 1
    Online Resource
    Online Resource
    Atomistic Modelling of Materials for Clean Energy Applications : hydrogen generation, hydrogen storage, and Li-ion battery (2013)
    [Erscheinungsort nicht ermittelbar] : KTH, Tillämpad materialfysik; Stockholm
    Details
    UID:
    (DE-627)1803575786
    Content: In this thesis, a number of clean-energy materials for hydrogen generation, hydrogen storage, and Li-ion battery energy storage applications have been investigated through state-of-the-art density functional theory. As an alternative fuel, hydrogen has been regarded as one of the promising clean energies with the advantage of abundance (generated through water splitting) and pollution-free emission if used in fuel cell systems. However, some key problems such as finding efficient ways to produce and store hydrogen have been hindering the realization of the hydrogen economy. Here from the scientific perspective, various materials including the nanostructures and the bulk hydrides have been examined in terms of their crystal and electronic structures, energetics, and different properties for hydrogen generation or hydrogen storage applications. In the study of chemisorbed graphene-based nanostructures, the N, O-N and N-N decorated ones are designed to work as promising electron mediators in Z-scheme photocatalytic hydrogen production. Graphene nanofibres (especially the helical type) are found to be good catalysts for hydrogen desorption from NaAlH4. The milestone nanomaterial, C60, is found to be able to significantly improve the hydrogen release from the (LiH+NH3) mixture. In addition, the energetics analysis of hydrazine borane and its derivative solid have revealed the underlying reasons for their excellent hydrogen storage properties. As the other technical trend of replacing fossil fuels in electrical vehicles, the Li-ion battery technology for energy storage depends greatly on the development of electrode materials. In this thesis, the pure NiTiH and its various metal-doped hydrides have been studied as Li-ion battery anode materials. The Li-doped NiTiH is found to be the best candidate and the Fe, Mn, or Cr-doped material follows. ; QC 20130925
    Note: Dissertation KTH, Tillämpad materialfysik; Stockholm 2013
    Language: English
    URN: urn:nbn:se:kth:diva-129220
    URL: kostenfrei
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  • 2
    Article
    Article
    Values in the Constitution : fifteen years of exploration (2020)
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    UID:
    (DE-627)1725690535
    ISBN: 9789813292598
    In: Constitutional development in China, 1982-2012, Singapore : Springer, 2020, (2020), Seite 283-298, 9789813292598
    In: year:2020
    In: pages:283-298
    Language: English
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    BSZ
  • 3
    Book
    Book
    The pseudokinase HPO-11 regulates genomic stability and aging process in C. elegans (2022)
    Freiburg im Breisgau
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    UID:
    (DE-604)BV049299070
    Format: ii, 144 Seiten , Illustrationen, Diagramme , 30 cm
    Note: Dissertation Albert-Ludwigs-Universität Freiburg 2022
    Language: English
    Keywords: Hochschulschrift
    URL: Inhaltsverzeichnis
    URL: Inhaltsverzeichnis
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    BVB
  • 4
    Book
    Book
    The pseudokinase HPO-11 regulates genomic stability and aging process in C. elegans (2022)
    Freiburg im Breisgau
    Details
    UID:
    (DE-627)1811488803
    Format: ii, 144 Seiten , Illustrationen, Diagramme
    Note: Dissertation Albert-Ludwigs-University Freiburg 2022
    Language: English
    Keywords: Caenorhabditis elegans ; Genetik ; Hochschulschrift
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  • 5
    Online Resource
    Online Resource
    Self-organization in planned Danwei and Dayuan: A case study of the transitional Houzaimen neighborhood of Nanjing in urban China (2018)
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    UID:
    (DE-627)184763298X
    In: ISUF International Conference (24. : 2017 : Valencia), City and territory in the globalization age, València : Editorial Universitat Politècnica de València, 2018, (2018), Artikel-ID 35
    In: year:2018
    In: elocationid:35
    Language: English
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  • 6
    Online Resource
    Online Resource
    Studies of nuclear encoded mitochondrial proteins in metabolism (2021)
    [Erscheinungsort nicht ermittelbar] : Inst för laboratoriemedicin / Dept of Laboratory Medicine
    Details
    UID:
    (DE-627)1828091898
    Content: Mitochondrial function is vital for human health. Inherited genetic disease can cause mitochondrial DNA (mtDNA) deficiency, disorders with generally poor prognosis. The majority of the genesinvolved in keeping a normal mitochondrial function are nuclear encoded. Deficiency in the nuclear encoded enzymes that provide building blocks for mtDNA synthesis, thymidine kinase 2 (TK2) and deoxyguanosine kinase (DGUOK), cause myopathy, encephalomyopathy and hepatocerebral disorders in humans. The nuclear encoded SLC25A10 is located in the mitochondrial inner membrane and is involved in regulation of cell metabolism. In the first study we hypothesized that SLC25A10 had a regulatory role in cancer metabolism. Since the antidiabetic drug metformin was known to reduce the risk for cancer and to alter cell energy production, we used the siSLC25A10 model to investigate effects of metformin. In the siSLC25A10 cell line, metformin significantly downregulated the SLC25A10 carrier, especially at low glucose conditions, at both mRNA and protein levels. Since SLC25A10 is a mitochondrial transporter, this lower expression affects the exchange of nutrients with the potential to alter metabolic pathways of cancer cells. In addition to cell culture studies, animal models are important tools to study mitochondrial functions. We constructed a DGUOK complete knockout mouse model to investigate the phenotype with the aim to find a model for mechanistic studies and treatment strategies. Interestingly, the Dguok−/− mice survived for more than 20 weeks despite very low mtDNA levels in liver tissue. Lipid metabolism as well as the de novo serine synthesis and the folate cycle were altered in the long surviving Dguok−/− mice. Two pyruvate kinase genes, PKLR and PKM, were active to supply pyruvate for the mitochondrial citric acid cycle (TCA cycle), which may be an explanation for the long-term survival although severely affected mitochondrial function. We also constructed a skeletal and cardiac muscle specific TK2 knockout mouse (mTk2 KO) and a liver specific TK2 knockout mouse (livTK2 KO). The mTk2 KO mice showed dilated hearts and markedly reduced adipose tissue, but livTK2 KO mice were not different compared to the control group. A severe decrease of mtDNA was found only in skeletal muscle and heart tissue in the mTk2 KO mice. The mTk2 KO mice survived for maximum 16 weeks, but livTK2 KO mice survived for more than one and a half years. The data suggested that TK2 was vital for mtDNA maintenance in cardiac and skeletal muscle, while Tk2 deficiency in liver could be compensated for. Despite low mtDNA levels in the liver of the livTK2 KO mice we did not observe any difference compared to the control mice. The receptor for angiotensin-converting enzyme 2 (ACE2), was also affected by mtDNA deficiency in mTk2 KO mice. Since ACE2 is a receptor for the SARS-CoV-2 virus, its regulation in relation to mitochondrial function may have important clinical implications.
    Note: Dissertation Inst för laboratoriemedicin / Dept of Laboratory Medicine 2021
    Language: English
    URL: kostenfrei
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  • 7
    Online Resource
    Online Resource
    Synthetic approaches of anticancer natural products, the flavaglines ; Approche synthétique de produits naturels anticancéreux, les flavaglines (2017)
    [Erscheinungsort nicht ermittelbar] : HAL CCSD
    Details
    UID:
    (DE-627)1803917334
    Content: We have developed three novel synthetizes of functionalized cyclopentenones based on unexpectedreactivities that we discovered.We also developed the first synthesis of flavaglines isostere substituted by a formylamino or mesylaminogroup on the position of 1b, and demonstrated the importance of a hydroxyl group on this position forcytotoxicity.Moreover, we contributed to the exploration of the therapeutic potential of flavaglines and another ligand ofprohibitins, fluorizoline, in the treatment of cancers and intestinal chronic inflammation, and also in theprevention of the cardiac adverse effects in anticancer treatments. ; Nous avons développé trois accès synthétiques performants à des cyclopentènones fonctionnalisées en exploitant des réactivités inattendues que nous avons découvertes. Nous avons aussi effectué la première synthèse d'isostères des flavaglines substitués par un groupement formylamino ou mésylamino en position 1b et ainsi démontré l'importance de l'hydroxyl en cette position pour la cytotoxicité de ces composés. De plus, nous avons aussi contribué à l'exploration du potentiel thérapeutique des flavaglines et d'un autre ligand des prohibitines, la fluorizoline, dans le traitement des cancers et de l'inflammation chronique des intestins, ainsi que dans la prévention des effets adverses des chimiothérapies au niveau cardiaque.
    Note: Dissertation HAL CCSD 2017
    Language: French
    URL: kostenfrei
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  • 8
    Online Resource
    Online Resource
    Identification of a binding target of triptolide and related studies (2012)
    [Erscheinungsort nicht ermittelbar] : The University of Hong Kong (Pokfulam, Hong Kong)
    Details
    UID:
    (DE-627)1803917342
    Content: Triptolide, a diterpene triepoxide extracted from traditional Chinese medicinal herb Tripterygium wilfordii Hook. F has been shown to have profound inhibitory effects against tumor progression, pathological angiogenesis and inflammation. However, the mechanisms by which triptolide exerts these effects remain unclear. To understand its cellular mode of action, biotinylated/desthiobiotinylated and fluorophore-labeled triptolide derivatives were used as probes to identify cellular proteins that bind to triptolide. By using two different approaches for screening drug-protein interactions, the most prominent cellular protein bound to triptolide was confirmed to be peroxiredoxin 1 (PRDX1). This result was validated by demonstrating the ability of triptolide or its conjugated probes to bind recombinant human PRDX1. Specificity of the drug-protein interaction was established by competitive inhibition of binding of fluorophore-labeled triptolide to PRDX1 by triptolide itself. Two binding sites of triptolide to PRDX1 were found, one of which being Cys173 as confirmed by orbitrap LC-MS/MS analysis. Further study by size exclusive chromatography revealed that triptolide altered the oligomeric state of PRDX1. The decameric form of PRDX1 was dissociated into lower molecular weight species in the presence of triptolide. This observation was responsible for attenuation of PRDX1's chaperone activity upon triptolide treatment, which was supported by evidence from both light scattering and native mass spectrometry studies. Functionally, triptolide's synergistic effect on stress-induced cell apoptosis may be mediated, at least in part, by the interaction of triptolide with PRDX1 and the consequent inhibition of its chaperone activity. Several natural products, Celastrol, Withaferin A and Radiciol were discovered as new PRDX1 inhibitors and confirmed to physically interact with PRDX1 and exert similar functional effects as triptolide. The interaction between PRDX1 and those natural products may shed light on the detailed mechanism of their biological actions and render PRDX1 a potential target for cancer therapy. ; published_or_final_version ; Chemistry ; Doctoral ; Doctor of Philosophy
    Note: Dissertation The University of Hong Kong (Pokfulam, Hong Kong) 2012
    Language: English
    DOI: 10.5353/th_b4819916
    URL: kostenfrei
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  • 9
    Online Resource
    Online Resource
    Analysis of the metaphorical meanings of symbols in Milan Kundera’s novels (2023)
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    UID:
    (DE-101)1287824757
    Format: Online-Ressource
    ISSN: 1613-3692
    Content: Abstract: Milan Kundera is one of the most influential writers in contemporary world literature. In his novels, there are many symbolic metaphors related to numbers, dreams, and animals. Combing through the plots of Kundera’s novels, we can discover that among all the numbers, seven and twenty are used most frequently. These two numbers have rich metaphorical meanings. Besides, there are many other digital metaphors in Kundera’s novels, including 6, 4, etc. Apart from number symbols, Kundera has also inserted various kinds of dream symbols in his artistic creation. For Kundera, dreams are not just an individual’s physical and psychological activities, but also a continuation and supplement of real life. It can be concluded that dream narration is a perfect medium for the author to express his philosophical ideology. In addition, dream symbols also serve as an important medium for Kundera to demonstrate narrative skills and present important themes. In Kundera’s novels, animal symbols are integrated with the plots, revealing the personal traits of the relevant characters, and mirroring their spiritual world at the same time. Besides, Kundera also expressed his ecological ethics through the narration of animals’ death. In conclusion, the metaphorical meanings of different symbols in Kundera’s novels play an active role in highlighting the themes, revealing the inner thoughts of the characters, showing the special features of the characters, and expressing the author’s philosophical thoughts. These symbols help Kundera to break the limitations of time and space, which has become an important part of his polyphonic art. What’s more, Kundera has also tried to expand the original metaphorical meanings of these symbols to create some new poetic meanings.
    In: volume:2023
    In: number:251
    In: year:2023
    In: pages:135-159
    In: extent:25
    In: Semiotica, Berlin [u.a.] : Mouton de Gruyter, 1969-, 2023, Heft 251 (2023), 135-159 (gesamt 25), 1613-3692
    Language: English
    DOI: 10.1515/sem-2021-0126
    URN: urn:nbn:de:101:1-2023050314100300839846
    URL: https://doi.org/10.1515/sem-2021-0126
    URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023050314100300839846
    URL: https://d-nb.info/1287824757/34
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  • 10
    Article
    Article
    To meet global challenges: ethical resources, culture, communities, and enterprises : book symposium on "East Asian ethical life and economy in the 21st century" (2023)
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    UID:
    (DE-602)gbv_1873040822
    ISSN: 1439-880X
    Note: Literaturverzeichnis: Seite 356-359
    In: Zeitschrift für Wirtschafts- und Unternehmensethik, Baden-Baden : Nomos, 2000, 24(2023), 3, Seite 372-375, 1439-880X
    In: volume:24
    In: year:2023
    In: number:3
    In: pages:372-375
    Language: German
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