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  • BSZ  (14)
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  • 1
    Online Resource
    Online Resource
    New York, NY : Humana Press
    UID:
    (DE-627)1654586005
    Format: 1 Online-Ressource (XII, 151 Seiten) , Illustrationen
    Edition: second edition
    ISBN: 9781493966790
    Series Statement: Current clinical urology
    Content: This fully updated and revised second edition address specifically some of the significant advances made in our understanding of the pathophysiology of penile cancer including discussion of the suspected role of the human papilloma virus in penile carcinogenesis. Similarly, the molecular pathways implicated in precancerous and penile cancer will be discussed as these are the present targets of novel therapeutic approaches to this disease. The text details the recent national and international diagnostic and treatment guidelines that have been developed by both the National Comprehensive Cancer Network© and the European Urological Association establishing evidence based standards upon which the care of penile cancer should be based. The text also covers significant advances made in the diagnostic and therapeutic approach to both primary tumors and inguinal nodal metastases resulting from penile cancer such as penile sparing surgery and minimally invasive inguinal lymph node surgery. The text will similarly highlights the improvement in cancer specific outcome in the management of loco-regionally advanced (N2/3) penile cancer managed by upfront systemic chemotherapy followed by consolidative surgery in appropriately selected patients based on recent prospective phase II data. It also covers the role of radiotherapy in the management of penile cancer for both primary tumors and/or at sites of regional or distant metastases. Finally, some of the novel systemic approaches being devised in the management of advanced penile cancer along with some upcoming international trials soon to be opened which likely will re-define the present therapeutic approaches to penile cancer are discussed. The Second Edition of Penile Cancer: Diagnosis and Treatment will constitute a comprehensive review of the above mentioned subjects in addition to a few select topics of high clinical relevance, with the readership predominantly consisting of urologists, medical and surgical oncologists, and other healthcare professionals
    Content: Understanding the Pathophysiology of Penile Cancer and Its Preneoplastic Lesions -- Diagnostic Tools in the Evaluation and Management of Penile Cancer -- Penile-Sparing Surgical Approaches in the Management of Primary Penile Tumours -- Dynamic Sentinel Node Biopsy and FDG-PET/CT for Lymph Node Staging in Penile Cancer -- Surgical Decision Making, Technical Considerations and Clinical Pearls in Therapeutic Inguinal Node Dissection Surgery for Penile Cancer -- Minimally Invasive Surgical Approaches to Inguinal Nodes in the Absence of Palpable Adenopathy -- Pelvic Lymph Node Dissection for Penile Cancer: Answering the Conundrum of When and How It Should Be Conducted -- Multmodal Approach to Locally Advanced and Metastatic Penile Cancer -- The Role of Radiotherapy in the Management of Penile Cancer
    Additional Edition: 9781493966776
    Additional Edition: Erscheint auch als Druck-Ausgabe 978-1-4939-6677-6
    Additional Edition: Printed edition 9781493966776
    Language: English
    Keywords: Peniskrebs
    URL: Volltext  (lizenzpflichtig)
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  • 2
    Online Resource
    Online Resource
    Totowa, NJ : Humana Press
    UID:
    (DE-627)1746264985
    Format: 1 online resource (168 pages)
    Edition: 1st ed.
    ISBN: 9781627033671
    Series Statement: Current Clinical Urology Ser.
    Content: Highlighting advances in surgical and radiotherapeutic approaches, in understanding of epidemiology, risk factors and pathophysiology of penile cancer, this book reviews novel diagnostic and therapeutic surgical methods and new paradigms in tumor management.
    Content: Intro -- Penile Cancer -- Copyright -- Foreword -- Contents -- Contributors -- 1: Epidemiology and Risk Factors for Penile Cancer -- Epidemiology -- Risk Factors in the Pathogenesis of Penile Cancer -- Human Papilloma Virus -- Intracellular Activity of HPV -- Presence of Foreskin -- Phimosis -- Infection -- Hygiene -- Zoophilia -- PUVA Treatment -- Socioeconomic Factors -- Smoking -- Premalignant Dermatoses -- Preventative Strategies -- Rationale for HPV Vaccination -- Circumcision -- Condom Use -- Conclusion -- References -- 2: Staging and Risk Stratification in Penile Cancer -- Staging Systems for Penile Cancer -- Jackson Staging System -- TNM/AJCC Staging System -- Imaging Studies Useful for Staging Penile Cancer -- Penile Imaging -- Cavernosography -- Sonography -- Computed Tomography and Positron Emission Tomography -- Magnetic Resonance Imaging -- Intercavernosal Alprostadil -- Endoluminal Coils -- Inguinal Imaging -- Cross-sectional Imaging -- PET/CT -- Lymphotropic Nanoparticle Enhanced MRI -- Dynamic Sentinel Lymph Node Biopsy -- Systemic Imaging -- Penile Cancer Prognosis -- Population Survival Estimates -- Survival Probability -- Relative Survival -- Case Fatality Ratio -- Patient-Related Prognostic Factors -- Age -- Multimorbidity -- Tumor-Related Prognostic Factors -- Degree of Local Invasion (T Stage) -- Tumor Depth (Thickness) -- Lymph Node Metastasis (N Stage) -- Lymphovascular Invasion -- Perineural Invasion -- Distant Organ Metastases (M Stage) -- Tumor Grade -- Tumor Location on Penis -- Histologic Subtype -- Human Papilloma Virus -- Molecular Markers -- Comprehensive Prognostic Tools in Penile Cancer -- Solsona and European Association of Urology (EAU) Risk Groups -- Gruppo Uro-Oncologico del Nord Est (GUONE) Nomogram -- Zini Risk Groups -- Thuret Nomogram -- Conclusion -- References.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9781627033664
    Additional Edition: Erscheint auch als Druck-Ausgabe 9781627033664
    Language: English
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  • 3
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    UID:
    (DE-627)1778707319
    Format: 1 Online-Ressource (240 p.)
    ISBN: 9789533073422 , 9789535165811
    Content: This book encompasses three sections pertaining to the topics of cancer biology, diagnostic markers, and therapeutic novelties. It represents an essential resource for healthcare professionals and scientist dedicated to the field of prostate cancer research. This book is a celebration of the significant advances made within this field over the past decade, with the hopes that this is the stepping stone for the eradication of this potentially debilitating and/or fatal malignancy
    Note: English
    Language: English
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  • 4
    Online Resource
    Online Resource
    New York, NY : Springer New York
    UID:
    (DE-627)873885775
    Format: 1 Online-Ressource (155 p)
    Edition: 2nd ed
    ISBN: 9781493966790
    Series Statement: Current Clinical Urology
    Content: Preface -- Contents -- Abbreviations -- Contributors -- 1: Understanding the Pathophysiology of Penile Cancer and Its Preneoplastic Lesions -- Epidemiology of Penile Cancer -- Risk Factors for Penile Carcinoma -- Pathophysiology -- Human Papillomavirus -- HPV-Mediated Pathway -- HPV-Independent Pathway -- Penile Cancer Precursor Lesions -- Condyloma Acuminatum -- Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor) -- Bowenoid Papulosis -- Lichen Sclerosus (Balanitis Xerotica Obliterans) -- Carcinoma In Situ (Erythroplasia of Queyrat and Bowen's Disease) -- Histologic Subtypes
    Content: Conclusions -- References -- 2: Diagnostic Tools in the Evaluation and Management of Penile Cancer -- Introduction -- Novel Image-Based Diagnostic Tools -- Evaluation and Management of the Primary Penile Lesion -- Evaluation and Management of Loco-Regional Metastatic Lymphatic Spread -- Penile Cancer Biomarkers -- p53 -- p16INK4a -- Ki-67 -- Proliferating Cell Nuclear Antigen -- C-Reactive Protein -- Cyclin D1 -- Other Biomarkers -- Conclusions -- References -- 3: Penile-Sparing Surgical Approaches in the Management of Primary Penile Tumours -- Introduction -- Basis for Penile-Preserving Surgery
    Content: Topical Therapies -- Suitable for Stage Tis Disease Only -- 5 % 5-Fluorouracil (5-FU) -- Imiquimod -- Laser Therapy -- For Stage Tis, But Has Been Used Up to Stage T2 Lesions -- Penile-Sparing Surgical Techniques -- Circumcision -- For Lesions Confined to the Prepuce -- Total Glans Resurfacing -- For Glanular Tis/Ta and Up to Stage T1a Disease -- Partial Glans Resurfacing -- For Isolated Foci of Tis/Ta Affecting 〈 50 % of Glans -- Moh's Micrographic Surgery -- For Stage T1a, But Has Been Used Up to Stage T3 -- Wide Local Excision/Partial Glansectomy
    Content: For Small, Discrete Lesions on the Glans Up to Stage T1a -- Glansectomy and Reconstruction -- For Stage T1b/T2 Tumours Confined to the Glans -- Distal Corporectomy/Partial Penectomy and Reconstruction -- For Stage T2b/Distal T3 Disease -- Conclusions -- References -- 4: Dynamic Sentinel Node Biopsy and FDG-­PET/CT for Lymph Node Staging in Penile Cancer -- Introduction -- Risk-Adapted Approach -- Dynamic Sentinel Node Biopsy -- FDG-PET/CT -- Conclusion -- References
    Content: 5: Surgical Decision-Making, Technical Considerations, and Clinical Pearls in Therapeutic Inguinal Node Dissection for Penile Cancer -- Surgical Decision-Making in Patients with CN +ve Penile Cancer -- Unresectable Inguinal Lymphadenopathy -- Role of Systemic Therapy in High-Volume Lymph Node Metastasis -- Technical Considerations Among Patients Undergoing Lymphadenectomy for Clinically Positive Nodes -- Initial Resection of Clinically Mobile Nodes Less Than 4 cm with No Overlying Skin Fixation -- Perioperative Care -- Patient Position -- Skin Incision -- Surgical Boundaries
    Content: Clinically Node Positive Inguinal Field
    Note: Description based upon print version of record
    Additional Edition: 9781493966776
    Additional Edition: Print version Spiess, Philippe E Penile Cancer : Diagnosis and Treatment New York, NY : Springer New York,c2016 9781493966776
    Language: English
    Keywords: Electronic books
    URL: Volltext  (lizenzpflichtig)
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  • 5
    Online Resource
    Online Resource
    Totowa, NJ : Humana Press
    UID:
    (DE-627)1652256881
    Format: Online-Ressource (X, 162 p. 50 illus., 47 illus. in color, digital)
    ISBN: 9781627033671
    Series Statement: Current Clinical Urology
    Content: Penile Cancer: Diagnosis and Management provides a comprehensive overview of penile cancer for medical and surgical urologists oncologists, and other healthcare professionals. This book highlights many of the significant advances made in this field, which include a discussion of penile-sparing surgical and radiotherapeutic approaches to select primary penile tumors typically of lower stage and grade as well as advances in our understanding of the epidemiology, risk factors, and pathophysiology of penile cancer
    Content: ​Penile Cancer: Diagnosis and Management provides a comprehensive overview of penile cancer for medical and surgical urologists oncologists, and other healthcare professionals. This book highlights many of the significant advances made in this field, which include a discussion of penile-sparing surgical and radiotherapeutic approaches to select primary penile tumors typically of lower stage and grade as well as advances in our understanding of the epidemiology, risk factors, and pathophysiology of penile cancer. The book also addresses many of the novel diagnostic and therapeutic surgical approaches to inguinal lymph nodes, including dynamic sentinel node biopsy and minimally invasive surgery. The authors also discuss many of the clinical pearls and surgical considerations that can optimize treatment outcomes while minimizing the morbidity and inherent risk of complications in patients undergoing an open inguinal lymph node dissection. Lastly, the volume presents a discussion of the paradigm shift in the management of bulky inguinal lymph node metastases from penile cancer consisting of neoadjuvant systemic chemotherapy followed by consolidative surgical resection, which can offer an improved likelihood of survival as shown in a recent phase 3 clinical trial. Penile Cancer: Diagnosis and Management will serve as a resource for clinicians and researchers seeking an overview on the current state of knowledge in penile cancer. The editor has gathered leading worldwide experts in this field who have written a very practical and useful textbook for clinicians in an attempt to optimize patient outcomes and promote the pivotal scientific advances made in recent years
    Note: Includes bibliographical references and index , Penile Cancer; Copyright; Foreword; Contents; Contributors; 1: Epidemiology and Risk Factors for Penile Cancer; Epidemiology; Risk Factors in the Pathogenesis of Penile Cancer; Human Papilloma Virus; Intracellular Activity of HPV; Presence of Foreskin; Phimosis; Infection; Hygiene; Zoophilia; PUVA Treatment; Socioeconomic Factors; Smoking; Premalignant Dermatoses; Preventative Strategies; Rationale for HPV Vaccination; Circumcision; Condom Use; Conclusion; References; 2: Staging and Risk Stratification in Penile Cancer; Staging Systems for Penile Cancer; Jackson Staging System , TNM/AJCC Staging SystemImaging Studies Useful for Staging Penile Cancer; Penile Imaging; Cavernosography; Sonography; Computed Tomography and Positron Emission Tomography; Magnetic Resonance Imaging; Intercavernosal Alprostadil; Endoluminal Coils; Inguinal Imaging; Cross-sectional Imaging; PET/CT; Lymphotropic Nanoparticle Enhanced MRI; Dynamic Sentinel Lymph Node Biopsy; Systemic Imaging; Penile Cancer Prognosis; Population Survival Estimates; Survival Probability; Relative Survival; Case Fatality Ratio; Patient-Related Prognostic Factors; Age; Multimorbidity , Tumor-Related Prognostic FactorsDegree of Local Invasion (T Stage); Tumor Depth (Thickness); Lymph Node Metastasis (N Stage); Lymphovascular Invasion; Perineural Invasion; Distant Organ Metastases (M Stage); Tumor Grade; Tumor Location on Penis; Histologic Subtype; Human Papilloma Virus; Molecular Markers; Comprehensive Prognostic Tools in Penile Cancer; Solsona and European Association of Urology (EAU) Risk Groups; Gruppo Uro-Oncologico del Nord Est (GUONE) Nomogram; Zini Risk Groups; Thuret Nomogram; Conclusion; References; 3: Pathology of Penile Cancer and Its Precursor Lesions , Anatomy and Histology of the PenisPremalignant Lesions of the Penis; Squamous Cell Carcinoma of the Penis; Patterns of Growth of Penile Squamous Cell Carcinoma; Morphologic Types of Penile Squamous Cell Carcinoma; Squamous Cell Carcinoma (Usual Type); Papillary Carcinoma, Not Otherwise Specified; Warty (Condylomatous) Carcinoma; Verrucous Carcinoma; Basaloid Carcinoma; Squamous Cell Carcinoma with Sarcomatoid Dedifferentiation; Other Squamous Carcinoma Types; Pathology Reporting and Predictive Pathology Features in Penile Squamous Cell Carcinoma , Pathologic Reporting of Penile Squamous Cell CarcinomaHistologic Subtype of Primary Tumor; Tumor Grade; Extent of Invasion and TNM Pathologic Stage; Lymphovascular Invasion; Perineural Invasion; Role of Human Papilloma Virus in Penile Squamous Cell Carcinoma; Other Tumors of the Penis; Conclusion; References; 4: Evolving Imaging Modalities in the Diagnosis and Staging of Penile Cancer; Introduction; Staging of the Primary Tumor; Physical Examination; Imaging for Staging of Primary Tumor; Ultrasound; Magnetic Resonance Imaging; Staging of the Regional Lymph Nodes; Physical Examination , Pathologic Features of the Primary Tumor as a Predictor of Regional Lymph Node Involvement , 1. Epidemiology and Risk Factors for Penile Cancer -- 2. Staging and Risk Stratification in Penile Cancer -- 3. Pathology of Penile Cancer and Its Precursor Lesions -- 4. Evolving Imaging Modalities in the Diagnosis and Staging of Penile Cancer -- 5. Penile-Sparing Approaches to Primary Penile Tumors -- 6. Surgical Concepts and Considerations of Inguinal Lymph Node Dissection for Penile Cancer -- 7. Minimally Invasive Surgical Approaches to Penile Cancer -- 8. Applications of Radiation Therapy in the Management of Penile Cancer -- 9. Multimodal Approach to the Management of Locally Advanced and Metastatic Penile Cancer -- 10. New Horizons in the Diagnosis, Treatment, and Prevention of Penile Cancer.
    Additional Edition: 9781627033664
    Additional Edition: Buchausg. u.d.T. Penile cancer New York [u.a.] : Humana Press, 2013 9781627033664
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Peniskrebs ; Peniskrebs ; Aufsatzsammlung
    URL: Volltext  (lizenzpflichtig)
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  • 6
    Book
    Book
    New York [u.a.] : Humana Press
    UID:
    (DE-627)1603927654
    Format: X, 162 S. , Ill., graph. Darst.
    ISBN: 9781627033664
    Series Statement: Current clinical urology
    Additional Edition: 9781627033671
    Additional Edition: Erscheint auch als Online-Ausgabe Spiess, Philippe E. Penile Cancer Totowa, NJ : Humana Press, 2013 9781627033671
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Peniskrebs ; Aufsatzsammlung
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  • 7
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    UID:
    (DE-627)1778705464
    Format: 1 Online-Ressource (392 p.)
    ISBN: 9789533073194 , 9789535165903
    Content: In this book entitled "Prostate Cancer - Diagnostic and Therapeutic Advances", we highlight many of the significant advances made in our treatment armamentarium of prostate cancer. The book is subdivided into four sections termed: 1) novel diagnostic approaches, 2) surgical treatments options, 3) radiation therapy and its potential sequelae, and 4) medical management and its treatment complications. After reading the present book , readers will be very familiar with the major clinical advances made in our multifaceted treatment approach to prostate cancer over the past decade.This book is a tribute to our pioneering urologists and allied healthcare professionals who have continually pushed forward our traditional therapeutic envelope
    Note: English
    Language: English
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  • 8
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    UID:
    (DE-627)1778705472
    Format: 1 Online-Ressource (530 p.)
    ISBN: 9789533073316 , 9789535165897
    Content: The present textbook highlights many of the exciting discoveries made in the diagnosis and treatment of prostate cancer over the past decade. International thought leaders have contributed to this effort providing a comprehensive and state-of-the art review of the signaling pathways and genetic alterations essential in prostate cancer. This work provides an essential resource for healthcare professionals and scientists dedicated to this field. This textbook is dedicated to the efforts and advances made by our scientific community, realizing we have much to learn in striving to some day in the not too distant future cure this disease particularly among those with an aggressive tumor biology
    Note: English
    Language: English
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  • 9
    Online Resource
    Online Resource
    New York, NY : Springer New York
    UID:
    (DE-627)1797576100
    Format: 1 Online-Ressource (155 pages)
    Edition: 2nd ed
    ISBN: 9781493966790
    Series Statement: Current Clinical Urology
    Additional Edition: 9781493966776
    Additional Edition: Erscheint auch als Druck-Ausgabe Spiess, Philippe E Penile Cancer New York, NY : Springer New York,c2016 9781493966776
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    UID:
    (DE-627)1772249866
    Format: 1 Online-Ressource(XIII, 154 p. 25 illus., 24 illus. in color.)
    Edition: 1st ed. 2021.
    ISBN: 9783030820602
    Content: Mechanism of Carcinogenesis and Progression -- Pathologic Features of Invasive Penile Carcinomas and Precursor Lesions -- Characterization of Penile Cancers with Comprehensive Genomic Profiling -- Functional and Psychosocial Impact of Penile Cancer Treatments -- Penile Sparing Surgical and Non-Surgical Approaches -- Management of Primary Penile Tumors - Partial and Total Penectomy -- In the Clinical Setting of Non-Palpable/Non-Bulky Inguinal Nodes -- Management of Bulky Inguinal/Pelvic Metastases in Squamous Penile Cancer -- Neoadjuvant and Adjuvant Multimodality Treatments for Patients with Lymph Node Involvement -- Management of Locally Recurrent Penile Cancer -- Management of Metastatic Penile Cancer -- Overview of Insightful Systemic Approaches -- Clinical Trials Corner.
    Content: This book provides a comprehensive and state-of the-art approach to caring for penile carcinoma patients and provides foundational information related to the molecular pathways implicated in penile carcinogenesis and progression. Penile carcinoma remains one of the most debilitating and life-altering malignancies to affect men, with significant impacts on quality of life, erectile function/sexual activity, and length of life. This book illuminates recent advances in penile cancer sparing treatment approaches and oncologically appropriate therapeutic options that help to maintain quality of life, sexual function, and intimacy for patients. It also elucidates recent understandings of human papilloma virus (HPV) and non-HPV driven pathways, which are suspected to have distinct treatment responses and prognoses. The book explores the management of inguinal lymph nodes in the setting of penile cancer, which can now be managed with the integration of key surgical principles/techniques including the adoption of minimally invasive surgery. Considering a multidisciplinary treatment approach for patients exhibiting either locally advanced or more widespread metastatic disease, the book introduces novel systemic therapies currently in development. Further, this book raises clinician awareness of the significant psychosocial impact of penile carcinoma on patients and their families. Penile Carcinoma: Therapeutic Principles and Advances provides readers with the necessary knowledge and insight to care for penile cancer patients with the use of truly state-of-the-art diagnostic and therapeutic approaches. Cancer patients and their families will greatly benefit from adoption of these principles and the accessibility of such advances to their personalized care.
    Additional Edition: 9783030820596
    Additional Edition: 9783030820619
    Additional Edition: 9783030820626
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030820596
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030820619
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030820626
    Language: English
    URL: Cover
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