Format:
1 Online-Ressource
ISSN:
1932-6203
Content:
Background: Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain. For an efficient treatment of glioblastomas it is necessary to deliver anti-cancer drugs across the intact BBB. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with poloxamer 188 hold great promise as drug carriers for brain delivery after their intravenous injection. In the present study the anti-tumour efficacy of the surfactant-coated doxorubicin-loaded PLGA nanoparticles against rat glioblastoma 101/8 was investigated using histological and immunohistochemical methods.
In:
PLOS ONE, San Francisco, California, US : PLOS, 2006-, Band 6, Heft 5 (06. Mai 2011), Artikel-ID: e19121, 1932-6203
In:
volume:6
In:
year:2011
In:
number:5
In:
day:06
In:
month:05
In:
extent:8
In:
elocationid:e19121
Language:
English
DOI:
10.1371/journal.pone.0019121
URN:
urn:nbn:de:hebis:30-113012