Format:
12
,
Illustrationen
ISSN:
1573-7373
Content:
Although pediatric low-grade gliomas (pLGG) are the most common pediatric brain tumors, patient-derived cell lines reflecting pLGG biology in culture are scarce. This also applies to the most common pLGG subtype pilocytic astrocytoma (PA). Conventional cell culture approaches adapted from higher-grade tumors fail in PA due to oncogene-induced senescence (OIS) driving tumor cells into arrest. Here, we describe a PA modeling workflow using the Simian Virus large T antigen (SV40-TAg) to circumvent OIS.
Note:
Gesehen am 22.01.2024
In:
Journal of neuro-oncology, Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983, 165(2023), 3 vom: Nov., Seite 467-478, 1573-7373
In:
volume:165
In:
year:2023
In:
number:3
In:
month:11
In:
pages:467-478
In:
extent:12
Language:
English
DOI:
10.1007/s11060-023-04500-6
URL:
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