Format:
Online-Ressource
ISSN:
1521-4141
Content:
Abstract: T helper type 1 (Th1) cells perform a critical role in fighting intracellular organisms, and interleukin‐12 (IL‐12) is known to promote a Thl response. This study was conducted to identify whether an IL‐12‐independent Th1 reaction is induced by the varicella‐zoster virus (VZV) in human beings. It was found that different intracellular microorganisms could induce IFNγ but not IL‐12 production. Induction of IFNγ production by VZV was associated with IFNα production and phosphorylation of both the signal transducer and activator of transcription‐1 (STAT‐1) and STAT‐4 in lymphocytes. In contrast, Bacillus Calmette‐Guerin (BCG) induced IL‐12 production in association with STAT‐4 but not STAT‐1 activation. Anti‐IFNα but not anti‐IL‐12 antibodies blocked the VZV‐induced Th1 polarization. A patient with an IL‐12 receptor β1 chain deficiency showed a normal VZV‐ but not a normal BCG‐induced Th1 reaction, further supporting the concept of an IFNα‐mediated, IL‐12‐independent Th1 reaction in response to certain intracellular infections. Identification of the early Th1 polarization induced by IFNα versus IL‐12 in response to specific viruses may enable the development of better therapeutic strategies tailored to different infections.
In:
volume:35
In:
number:12
In:
year:2005
In:
pages:3664-3672
In:
extent:9
In:
European journal of immunology, Weinheim : Wiley-VCH, 1971-, 35, Heft 12 (2005), 3664-3672 (gesamt 9), 1521-4141
Language:
English
DOI:
10.1002/eji.200526258
URN:
urn:nbn:de:101:1-2023091207273799621091
URL:
https://doi.org/10.1002/eji.200526258
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023091207273799621091
URL:
https://d-nb.info/1302239805/34
URL:
https://doi.org/10.1002/eji.200526258