Format:
Online-Ressource
ISSN:
1420-3049
Content:
YS-121 [2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid] is the result of target-oriented structural derivatization of pirinixic acid. It is a potent dual PPARα/γ-agonist, as well as a potent dual 5-LO/mPGES-1-inhibitor. Additionally, recent studies showed an anti-inflammatory efficacy in vivo. Because of its interference with many targets, YS-121 is a promising drug candidate for the treatment of inflammatory diseases. Ongoing preclinical studies will thus necessitate huge amounts of YS-121. To cope with those requirements, we have optimized the synthesis of YS-121. ...
In:
Molecules, Basel : MDPI, 1996-, Band 16, Heft 12 (2011), Seite 10013-10028, 1420-3049
In:
volume:16
In:
year:2011
In:
number:12
In:
pages:10013-10028
In:
extent:16
Language:
English
DOI:
10.3390/molecules161210013
URN:
urn:nbn:de:hebis:30:3-253130