Format:
16
ISSN:
1090-2120
Content:
1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the α-fucosidases of T. maritima (bacterial origin) and B. taurus (bovine origin). The N-alkyl derivatives were inactive against the bacterial fucosidase, while inhibiting the bovine enzyme. Docking of inhibitors to homology models, generated for the bovine and human fucosidases, was carried out. N-Decyl-DFJ was toxic to cancer cell lines and was more potent than the other N-alkyl DFJs studied.
Note:
Available online 04 December 2018
,
Gesehen am 18.09.2019
In:
Bioorganic chemistry, San Diego, Calif. : Elsevier, 1971, 84(2019), Seite 418-433, 1090-2120
In:
volume:84
In:
year:2019
In:
pages:418-433
In:
extent:16
Language:
English
DOI:
10.1016/j.bioorg.2018.12.003