Format:
7
ISSN:
1556-1380
Content:
Thymomas are tumors of thymic epithelial cells. They associate more often than any other human tumors with various autoimmune diseases; myasthenia gravis is the commonest, occurring in 10-50% of thymoma patients, depending on the World Health Organization-defined histologic subtype. Most thymomas generate many polyclonal maturing T lymphocytes but in disorganized microenvironments Failure to induce self-tolerance may be a key factor leading to the export of potentially autoreactive CD4+ progeny, thus predisposing to autoimmune diseases. Normally, the master Autoimmune Regulator promotes expression of peripheral tissue-restricted antigens such as insulin by medullary thymic epithelial cells and induction of tolerance to them. The failure of ∼95% of thymomas to express autoimmune regulator is another feature potentially contributing to autoimmunity.
Note:
Online veröffentlicht am 20. November 2015
,
Gesehen am 23.05.2023
In:
Journal of thoracic oncology, Amsterdam : Elsevier, 2006, 5(2010), 10, Supplement 4 vom: Okt., Seite S266-S272, 1556-1380
In:
volume:5
In:
year:2010
In:
number:10
In:
month:10
In:
supplement:Supplement 4
In:
pages:S266-S272
In:
extent:7
Language:
English
DOI:
10.1097/JTO.0b013e3181f1f63f
URL:
Volltext
(lizenzpflichtig)
URL:
Volltext
(lizenzpflichtig)