In:
Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 73, No. 4 ( 2016), p. 312-317
Abstract:
Background/Aim. Although chlorpromazine (CPZ) is an antipsychotic drug widely
used in clinical practice for a long time, its mechanism of action has not
been entirely defined. An extremely difficult managing of patients acutely
poisoned with CPZ is additional reason for detailed studying its toxicity
mechanisms. In this clinical study, we investigated whether the oxidative
stress (OS) mediates CPZ toxic effects in the exposed patients. Methods. The
patients were organized into 3 groups: the T-group - hospitalized patients
receiving therapeutic doses of 75-150 mg CPZ/day; the overdosed group,
divided into two subgroups: the group M and the group S - mildly (CPZ serum
concentration: 0.21 ? 0.05 mg/L) and severely (CPZ serum concentration: 2.66
? 0.25 mg/L) poisoned patients, respectively, and the group C (control group
of healthy volunteers). Oxidative stress parameters [total antioxidative
status (TAS) and malondialdehyde (MDA) in plasma)] and superoxide dismutase
(SOD) activity in erythrocytes were measured spectrophotometrically, and CPZ
concentrations in serum were monitored chromatographically. One set of
measurements was performed in the group C and T, whereas two sets of
measurements (after 24 hours and 48 hours) were done in the poisoned
patients, groups M and S. Results. A decrease of TAS and increase of SOD
activity were obtained in both subgroups of the poisoned patients, compared
to the controls and the group receiving therapeutic doses of CPZ. A
significant increase of MDA was achieved in severely poisoned patients,
compared to all other groups. Conclusion. Changed oxidative stress
parameters in patients poisoned with chlorpromazine indicate involvement of
oxidative stress in the toxicity mechanism(s) of chlorpromazine.
Type of Medium:
Online Resource
ISSN:
0042-8450
,
2406-0720
DOI:
10.2298/VSP140423047D
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2016
detail.hit.zdb_id:
2169819-3
SSG:
15,3
