UID:
almahu_9948171413502882
Format:
1 online resource (xvii, 598 pages) :
,
illustrations, charts
Edition:
Second edition.
ISBN:
0-12-809394-3
Note:
Cover -- Title page -- Copyright page -- Contents -- List of Contributors -- Preface and Acknowledgments -- Part I - Cellular and molecular morphogenesis of the nervous system -- Chapter 1 - Brain Morphogenesis and Developmental Neurotoxicology -- I - Introduction -- II - Marr proposed computational models be integrated over three levels -- III - Morphogenetic features emerge from interactions across multiple levels of biological organization -- A - Sensory Pathways Encode Features of Sense Organs and the Environment -- B - Neurovascular Coupling (NVC) is Essential to Brain Connectivity -- C - Engrams Exist at Multiple Structural Levels -- IV - Whole Brain Assessment of Larval Zebrafish Reveals Patterns of Connectivity -- V - Conclusions: morphology informs predictive models of developmental neurotoxicity -- Acknowledgments -- Abbreviations -- References -- Further Reading -- Chapter 2 - Neural Cell Adhesion Molecules in Normal and Abnormal Neural Development -- I - Introduction -- II - The expression levels of NCAM and PSA-NCAM during the development -- III - Regulating PSA-NCAM expression and cell migration -- IV - Requirement of PSA-NCAM for activity-induced synaptic plasticity -- Acknowledgments -- References -- Chapter 3 - Neurite Development and Neurotoxicity -- I - Introduction -- A - Molecular Mechanisms Underlying Neurite Growth -- 1 - Applications in Neurotoxicology: Addressing Molecular Mechanisms -- B - Genetic Modulation of Neurite Development -- 1 - Examples of Genetic Modulation by Neurotoxicants -- C - Cell Death Mechanisms and Neurite Development -- 1 - Relevance to Neurotoxicology: Addressing Cell Death Mechanisms -- D - Stem/Progenitor Cells and Neurite Development -- 1 - Applications of Stem Cell Technology for Neurotoxicology -- E - Neurite Growth and State-of-the-Art Techniques -- 1 - Overview -- 2 - High-Content Imaging.
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3 - Applications Using HCI -- 4 - Three-Dimensional Approaches -- a - Organotypic Culture Technique for Assessing Neurite Growth -- b - 3D Cell Culture -- 5 - Nanotechnology and Neurite Development -- a - Applications of Nanotechnology -- b - Neurotoxicity of Nanomaterials -- 6 - Bioengineering and Neurite Development -- a - De Novo Measurement of Neurite Growth -- b - Bioengineering-Induced Neurotoxicity Related to Neurite Development -- II - Conclusions -- Acknowledgment -- References -- Further Reading -- Chapter 4 - Myelin: Structure, Function, Pathology, and Targeted Therapeutics -- I - Introduction -- II - Myelin architecture and assembly: old and new perspectives -- A - Traditional View of Myelin -- B - Recent Findings: Myelin Structure and Functions -- III - Neuron-glia communication and its regulation -- IV - Myelinating glial cell lineages in peripheral and central nervous systems -- A - Schwann Cells -- B - Oligodendrocytes -- V - Chemical composition of vertebrate myelin -- VI - Dysmyelination: myelin mutant models for dysmyelination -- VII - Demyelination: effect of various factors on developmental myelination -- A - Malnutrition -- B - Thyroid Deficiency -- VIII - Remyelination and CNS disorders: myelin to axonal regeneration -- IX - Newer treatment strategies for myelin disorders -- X - Conclusions -- Acknowledgment -- References -- Part II - Developmental neurobiology/toxicology -- Chapter 5 - Neurotrophic Factors -- I - Neurotrophic factors -- II - Expression pattern and regulation -- III - Neurotrophin receptors -- IV - Neurotrophic factors in cell survival and cell death -- V - Neurotrophins and synaptic plasticity -- VI - Neurotrophins and behavior -- VII - Other neurotrophic factors -- VIII - Clinical correlates to neurodegenerative disorders -- IX - Clinical correlates to psychiatric disorders -- X - Genetic polymorphisms.
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XI - Neurotrophins as therapeutic agents -- References -- Chapter 6 - Serotonin Signaling as a Target for Craniofacial Embryotoxicity -- I - Introduction-Serotonin and Embryonic Development -- II - Serotonin signal transduction -- A - Serotonin Release and Selective Serotonin Reuptake Inhibitors -- B - Serotonin Receptors and Receptor Antagonists -- III - Role of serotonin in development -- A - Placental Transfer of Serotonin -- B - Serotonin and Craniofacial Development -- C - Embryonic Precursors of the Facial Skeleton -- D - Serotonin and Neural Crest Cells -- E - Importance of Proper Orofacial Osteogenesis to Orofacial Development -- F - Serotonin and Bone Development -- IV - Conclusions -- References -- Chapter 7 - Neurotoxic and Neurotrophic Effects of GABAergic Agents on the Developing Brain -- I - Introduction -- II - The GABAergic system during development -- III - GABAergic agents and consequences of perturbations of GABAergic system development -- IV - Animal models of GABAergic system perturbation -- V - In vitro and cell-based models of GABAergic system perturbation during neurodevelopment -- VI - Bioinformatic and computational approaches -- VII - Protecting the developing GABAergic system: prospects for the future -- References -- Chapter 8 - Neural Stem Cell Biology and Application to Developmental Neurotoxicity Assessment -- I - Neural stem cells in the developing brain -- II - Neural stem cells in the adult brain -- III - NSCs-derived from embryonic stem cells and induced pluripotent stem cells -- IV - Application of NSCs to developmental neurotoxicity assessments -- A - Status of Developmental Neurotoxicity Tests -- B - Considerations on the Utilization of NSCs as an In Vitro Model for DNT Assessment -- V - Conclusions -- Acknowledgment -- References -- Further Reading.
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Chapter 9 - Apoptosis as a Mechanism of Developmental Neurotoxicity -- I - Introduction -- II - Molecular Mechanisms of Apoptosis in the Developing Nervous System -- III - Physiological Roles of Apoptosis in Neurodevelopment -- IV - Chemical-Induced Apoptosis -- A - Anesthetics -- B - Polychlorinated Biphenyls -- C - Zinc -- V - Conclusions -- References -- Further Reading -- Chapter 10 - Periods of Susceptibility: Interspecies Comparison of Developmental Milestones During Ontogenesis of the Central Ne... -- I - Introduction -- II - Overview of central nervous system development -- A - Neural Tube Formation -- B - Cellular Components of the Neural Plate -- C - Primary Neurulation -- D - Formation of Cerebral Vesicles -- E - Secondary Neurulation -- F - Intramural Development and Nuclei -- III - Developmental milestones -- A - Externally Observed Central Nervous System Developmental Milestones -- B - Internally Observed Central Nervous System Developmental Milestones -- C - Developmental Milestones Related to Myelination -- D - Developmental Milestones of Cerebral Cortex -- IV - Conclusions -- References -- Chapter 11 - Modeling the Neurovascular Unit In Vitro and In Silico -- I - Introduction -- II - Animal models of BBB development and function -- III - Cell-based models -- IV - Static three-dimensional (3D) models -- V - Organotypic culture models (OCMs) and microphysiological systems(MPS) -- VI - Implementing in vitro BBB models for DNT -- VII - In silico models: BBB permeability -- VIII - In silico models: virtual NVU -- IX - Summary and conclusions -- Acknowledgments -- References -- Chapter 12 - Zebrafish as a Model for Developmental Biology and Toxicology -- I - Introduction -- II - Developmental biology -- A - Gastrulation -- B - Organogenesis -- C - Neurodevelopment -- D - Neurulation -- E - Neurogenesis -- F - Eye -- G - Brain.
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H - Behavior -- III - Developmental toxicology -- A - Assessments and Chemicals Screened -- 1 - Fish Embryo Acute Toxicity (FET) Test -- 2 - Morphological Screens -- 3 - Behavioral Assays -- B - Advancements -- IV - Concordance with mammalian models -- V - Conclusions -- References -- Chapter 13 - Using Caenorhabditis elegans to Study Neurotoxicity -- I - Introduction -- II - Studies of specific neurotoxins -- A - Manganese -- B - Selenium -- C - Methylmercury -- D - Other Toxins -- III - Anesthetic-induced neurotoxicity -- IV - Conclusions -- References -- Part III - Synaptogenesis and neurotransmission -- Chapter 14 - Human 3D In Vitro Models for Developmental Neurotoxicity -- I - Developmental neurotoxicity represents a societal testing need -- II - The current testing approach for DNT in vivo and in vitro does not satisfy our needs -- III - The process of developing in vitro strategies for DNT -- IV - The development of a reproducible BMPS for modeling neurodevelopment and testing its perturbation -- V - Ongoing developments of the mini-brain -- VI - Conclusions -- Acknowledgment -- References -- Chapter 15 - Ontogeny of Monoamine Neurotransmitters -- I - Introduction -- II - Innervation of terminal fields -- A - Ontogeny of Dopaminergic Innervation -- B - Ontogeny of Noradrenergic Innervation -- C - Ontogeny of Serotonergic Innervation -- III - Neurochemical synaptogenesis -- A - Neurotransmitter Content -- 1 - Dopamine -- 2 - Norepinephrine -- 3 - Serotonin -- B - Biosynthetic Enzymes -- 1 - Tyrosine Hydroxylase -- 2 - Dopamine β-Hydroxylase (DβH) -- 3 - Tryptophan Hydroxylase (TPH) -- C - Reuptake Systems -- 1 - High-Affinity DA Uptake -- 2 - High-Affinity NE Uptake -- 3 - High-Affinity 5-HT Uptake -- D - Monoaminergic Receptors -- 1 - Dopaminergic Receptors -- 2 - Noradrenergic Receptors -- 3 - Serotonergic Receptors.
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a - Developmental neurotoxicity of amphetamine-type stimulants.
Additional Edition:
ISBN 0-12-809405-2
Language:
English
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