Format:
Online-Ressource
ISSN:
1521-4141
Content:
Abstract: We generated a novel tumor necrosis factor (TNF) null mutation using Cre‐loxP technology. Mice homozygous for this mutation differ from their “conventional” counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these novel TNF‐knockout mice supports the previously disputed notion of the involvement of TNF‐TNFR1 signaling in PP organogenesis. Availability of TNF‐knockout strains both with and without PP enables more definitive studies concerning the roles of TNF and PP in various immune functions and disease conditions. Here, we report that systemic ablation of TNF, but not the presence of PP per se, is critical for protection against intestinal Listeria infection in mice.
In:
volume:35
In:
number:5
In:
year:2005
In:
pages:1592-1600
In:
extent:9
In:
European journal of immunology, Weinheim : Wiley-VCH, 1971-, 35, Heft 5 (2005), 1592-1600 (gesamt 9), 1521-4141
Language:
English
DOI:
10.1002/eji.200526119
URN:
urn:nbn:de:101:1-2023090806211636892114
URL:
https://doi.org/10.1002/eji.200526119
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023090806211636892114
URL:
https://d-nb.info/1301856819/34
URL:
https://doi.org/10.1002/eji.200526119
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