Format:
Online-Ressource
ISSN:
1615-9314
Content:
Abstract: In the postgenomic era, proteomics has become a dominant field for identifying and quantifying the complex protein machinery of the cell. The expression levels, posttranslational modifications, and specific interactions of proteins control the biology of such processes as development, differentiation, and signal transduction. Studies of the proteins involved in these processes often lead to a better understanding of biology and of human disease. Powerful separation techniques and sensitive detection methods enable researchers to untangle these complicated networks of processes. CE coupled with either MS or LIF are two of the techniques that make this possible. This review will cover proven CE‐based methods for proteomics on the cell and tissue level and their application in biological and clinical studies, relevant new developments in enabling technology such as microfluidic CE‐MS demonstrated on model systems, and comment on the future of CE in proteomics.
In:
volume:32
In:
number:8
In:
year:2009
In:
pages:1175-1188
In:
extent:14
In:
Journal of separation science, Weinheim : Wiley-VCH, [2000]-, 32, Heft 8 (2009), 1175-1188 (gesamt 14), 1615-9314
Language:
English
DOI:
10.1002/jssc.200800592
URN:
urn:nbn:de:101:1-2023041411340325220212
URL:
https://doi.org/10.1002/jssc.200800592
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023041411340325220212
URL:
https://d-nb.info/1286251303/34
URL:
https://doi.org/10.1002/jssc.200800592
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