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  • 1
    Book
    Book
    Washington, DC : American Chemical Society
    UID:
    (DE-627)543722686
    Format: S. 3363 - 3714 , Ill., graph. Darst.
    Series Statement: Chemical reviews 107.2007,8
    Language: English
    Keywords: Genomik ; Proteomanalyse
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  • 2
    UID:
    (DE-101)1311691715
    Format: Online-Ressource
    ISSN: 1522-2683
    Content: Abstract: Large‐scale DNA sequencing is creating a sequence infrastructure of great benefit to protein biochemistry. Concurrent with the application of large‐scale DNA sequencing to whole genome analysis, mass spectrometry has attained the capability to rapidly, and with remarkable sensitivity, determine weights and amino acid sequences of peptides. Computer algorithms have been developed to use the two different types of data generated by mass spectrometers to search sequence databases. When a protein is digested with a site‐specific protease, the molecular weights of the resulting collection of peptides, the mass map or fingerprint, can be determined using mass spectrometry. The molecular weights of the set of peptides derived from the digestion of a protein can then be used to identify the protein. Several different approaches have been developed. Protein identification using peptide mass mapping is an effective technique when studying organisms with completed genomes. A second method is based on the use of data created by tandem mass spectrometers. Tandem mass spectra contain highly specific information in the fragmentation pattern as well as sequence information. This information has been used to search databases of translated protein sequences as well as nucleotide databases such as expressed sequence tag (EST) sequences. The ability to search nucleotide databases is an advantage when analyzing data obtained from organisms whose genomes are not yet completed, but a large amount of expressed gene sequence is available (e.g., human and mouse). Furthermore, a strength of using tandem mass spectra to search databases is the ability to identify proteins present in fairly complex mixtures.
    In: volume:19
    In: number:6
    In: year:2005
    In: pages:893-900
    In: extent:8
    In: Electrophoresis, Weinheim : Wiley-Blackwell, 1980-, 19, Heft 6 (2005), 893-900 (gesamt 8), 1522-2683
    Language: English
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  • 3
    Book
    Book
    Washington, DC : American Chemical Soc.
    UID:
    (DE-604)BV022619835
    Format: 7 S., S. 3364 - 3714 , Ill., graph. Darst.
    Series Statement: Chemical reviews 107,8
    Note: Einzelaufnahme eines Zeitschr.-H.
    Language: English
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  • 4
    UID:
    (DE-101)1286251303
    Format: Online-Ressource
    ISSN: 1615-9314
    Content: Abstract: In the postgenomic era, proteomics has become a dominant field for identifying and quantifying the complex protein machinery of the cell. The expression levels, posttranslational modifications, and specific interactions of proteins control the biology of such processes as development, differentiation, and signal transduction. Studies of the proteins involved in these processes often lead to a better understanding of biology and of human disease. Powerful separation techniques and sensitive detection methods enable researchers to untangle these complicated networks of processes. CE coupled with either MS or LIF are two of the techniques that make this possible. This review will cover proven CE‐based methods for proteomics on the cell and tissue level and their application in biological and clinical studies, relevant new developments in enabling technology such as microfluidic CE‐MS demonstrated on model systems, and comment on the future of CE in proteomics.
    In: volume:32
    In: number:8
    In: year:2009
    In: pages:1175-1188
    In: extent:14
    In: Journal of separation science, Weinheim : Wiley-VCH, [2000]-, 32, Heft 8 (2009), 1175-1188 (gesamt 14), 1615-9314
    Language: English
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  • 5
    UID:
    (DE-627)166347446X
    Format: xi, 331 Seiten , Illustrationen
    Edition: Second edition
    ISBN: 9781118279243
    Content: "An update to the popular guide to proteomics technology applications in biomedical research Building on the strength of the original edition, this book presents the state of the art in the field of proteomics and offers students and scientists new tools and techniques to advance their own research. Written by leading experts in the field, it provides readers with an understanding of new and emerging directions for proteomics research and applications. Proteomics for Biological Discovery begins by discussing the emergence of proteomics technologies and summarizing the potential insights to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are thoroughly covered, from underlying concepts to limitations and future directions. Later chapters provide an overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, applied proteomics, and bioinformatics relevant to proteomics. Chapters cover: Quantitative Proteomics for Differential Protein Expression Profiling; Protein Microarrays; Protein Biomarker Discovery; Biomarker Discovery using Mass Spectrometry Imaging; Protein-Protein Interactions; Mass Spectrometry Of Intact Protein Complexes; Crosslinking Applications in Structural Proteomics; Functional Proteomics; High Resolution Interrogation of Biological Systems via Mass Cytometry; Characterization of Drug-Protein Interactions by Chemoproteomics; Phosphorylation; Large-Scale Phosphoproteomics; and Probing Glycoforms of Individual Proteins Using Antibody-Lectin Sandwich Arrays. Presents a comprehensive and coherent review of the major issues in proteomic technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Features new coverage of mass spectrometry for high throughput proteomic measurements, and novel quantitation strategies such as spectral counting and stable isotope labeling Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Offers new chapters on biomarker discovery, global phosphorylation analysis, proteomic profiling using antibodies, and single cell mass spectrometry Proteomics for Biological Discovery is an excellent advanced resource for graduate students, postdoctoral fellows, and scientist ...
    Language: English
    Subjects: Biology
    RVK:
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  • 6
    Book
    Book
    Hoboken, N.J. : John Wiley & Sons
    UID:
    (DE-627)1624282148
    Format: XVI, 326 S. , Ill., graph. Darst.
    ISBN: 0471160059 , 9780471160052
    Note: Includes bibliographical references and index
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Biowissenschaften ; Proteomanalyse ; Proteomanalyse ; Biowissenschaften ; Mikroorganismus ; Proteomanalyse ; Biologie ; Biowissenschaften ; Physiologie ; Genetik ; Aufsatzsammlung
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  • 7
    UID:
    (DE-605)HT017795072
    Format: XVII, 349 S.
    ISBN: 9780415704984 , 9780415704991
    Additional Edition: Erscheint auch als Online-Ausgabe 9781315885025
    Language: English
    Keywords: Visuelles Lernen ; Lernerfolg ; Lehr-Lern-Forschung
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  • 8
    UID:
    (DE-605)(DE-132)000408108
    Format: XIX, 349 S.
    ISBN: 9783834015006
    Note: Literaturangaben
    Language: German
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  • 9
    UID:
    (DE-605)(DE-229)0745019
    Format: XIX, 349 S.
    Edition: 1. Aufl.
    ISBN: 9783834015006 , 3834015008
    Note: Literaturverz. S. 313 - 323.
    Language: German
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  • 10
    UID:
    (DE-604)BV041357310
    Format: XVII, 349 S.
    Edition: 1. publ.
    ISBN: 9780415704984 , 9780415704991
    Series Statement: Educational psychology
    Content: "Now in this latest book, John Hattie has joined forces with cognitive psychologist Greg Yates to build on the original data and legacy of the Visible Learning project, showing how it's underlying ideas and the cutting edge of cognitive science can form a powerful and complimentary framework for shaping learning in the classroom and beyond. Visible Learning and the Science of Learning explains the major principles and strategies of learning, outlining why it can be so hard sometimes, and yet easy on other occasions. Aimed at teachers and students, it is written in an accessible and engaging style and can be read cover to cover, or used on a chapter-by-chapter basis for essay writing or staff development. The book is structured in three parts - 'learning within classrooms', 'learning foundations', which explains the cognitive building blocks of knowledge acquisition and 'know thyself' which explores, confidence and self-knowledge. It also features extensive interactive appendices containing study guide questions to encourage critical thinking, annotated bibliographic entries with recommendations for further reading, links to relevant websites and YouTube clips, and the meta-analyses from the original Visible Learning project by rank order. Throughout, the authors draw upon the latest international research into how the learning process works and how to maximise impact on students, covering such topics as: - teacher personality; - expertise and teacher-student relationships; - how knowledge is stored and the impact of cognitive load; - thinking fast and thinking slow; - the psychology of self-control; - the role of conversation at school and at home; - invisible gorillas and the IKEA effect; - digital native theory; - myths and fallacies about how people learn"..
    Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-1-315-88502-5
    Language: English
    Subjects: Education , Psychology , Sociology
    RVK:
    RVK:
    RVK:
    RVK:
    Keywords: Visuelles Lernen ; Lernerfolg ; Lehr-Lern-Forschung ; Lernerfolg ; Unterrichtsführung ; Lehr-Lern-Forschung ; Lernpsychologie
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