Format:
Online-Ressource
ISSN:
1862-8354
Content:
Abstract: The testis is a unique organ responsible for sperm production and androgen secretion in men. To analyze the human testis proteome on a large scale, 1‐D SDS‐PAGE and RP‐LC‐MS/MS were applied and 1430 proteins in the human testis were identified. Both the false‐positive rate of peptides and protein identification confidence scores were calculated in the present study. Subsequent bioinformatics analysis of the human testis proteome revealed 39 testis‐specific proteins which may be important for testis functions. And a large family of proteins were identified possibly involved in alternative splicing, which may also be involved in testis‐specific splicing events and explain why splicing is so prevalent in the testis. Compared with the studies on brain proteome, researches on the testis proteome is still very limited. Studies of these proteins will give a better understanding on the function of the testis. Moreover, this large‐scale identification of testis proteins in humans could serve as a reference for future studies on the mechanisms underlying male infertility, searching for potential contraceptive targets, and developing new treatments for testis cancer.
In:
volume:2
In:
number:12
In:
year:2008
In:
pages:1651-1657
In:
extent:7
In:
Proteomics / Clinical applications. Clinical applications, Weinheim : Wiley VCH, 2007-, 2, Heft 12 (2008), 1651-1657 (gesamt 7), 1862-8354
Language:
English
DOI:
10.1002/prca.200780120
URN:
urn:nbn:de:101:1-2023072713373712959489
URL:
https://doi.org/10.1002/prca.200780120
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023072713373712959489
URL:
https://d-nb.info/1297462505/34
URL:
https://doi.org/10.1002/prca.200780120
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