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  • English  (42)
  • 1
    UID:
    (DE-627)37024527X
    Format: XI, 221 S , Ill., graph. Darst , 25 cm
    Edition: 2., rev. and extended ed.
    ISBN: 3805576560
    Series Statement: Contributions to microbiology 11
    Note: Includes bibliographical references and index
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    RVK:
    Keywords: Prion ; Spongiöse subakute Encephalopathie ; Jakob-Creutzfeldt-Syndrom ; Prion ; Spongiöse subakute Encephalopathie ; Jakob-Creutzfeldt-Syndrom ; Aufsatzsammlung
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  • 2
    UID:
    (DE-603)226007308
    Format: Online-Ressource
    ISSN: 1471-2334
    Content: Background: Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses. Since the potential risk of laboratory-acquired infections with VACV persists and since the adverse effects of vaccination with VACV are described, the replacement of VACV by the modified vaccinia Ankara strain (MVA) was studied by testing the activity of different chemical biocides in three German laboratories. Methods: The inactivating properties of different chemical biocides (peracetic acid, aldehydes and alcohols) were tested in a quantitative suspension test according to the DVV/RKI guideline. All tests were performed with a protein load of 10% fetal calf serum with both viruses in parallel using different concentrations and contact times. Residual virus was determined by endpoint dilution method. Results: The chemical biocides exhibited similar virucidal activity against VACV and MVA. In three cases intra-laboratory differences were determined between VACV and MVA - 40% (v/v) ethanol and 30% (v/v) isopropanol are more active against MVA, whereas MVA seems more stable than VACV when testing with 0.05% glutardialdehyde. Test accuracy across the three participating laboratories was high. Remarkably inter-laboratory differences in the reduction factor were only observed in two cases. Conclusions: Our data provide valuable information for the replacement of VACV by MVA for testing chemical biocides and disinfectants. Because MVA does not replicate in humans this would eliminate the potential risk of inadvertent inoculation with vaccinia virus and disease in non-vaccinated laboratory workers.
    In: BMC infectious diseases, London : BioMed Central, 2001-, Band 10, Heft 185 (2010), 1471-2334
    In: volume:10
    In: year:2010
    In: number:185
    In: extent:8
    Language: English
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  • 3
    UID:
    (DE-627)80116012X
    Format: Online-Ressource (xi, 221 p) , ill
    Edition: 2nd, rev. and extended ed
    Edition: Online-Ausg.
    ISBN: 1417522569 , 9781417522569
    Series Statement: Contributions to microbiology v. 11
    Note: Includes bibliographical references and index , ""Contents""; ""Dedication in Remembrance of Andreas Scheid (1941�2001)""; ""Note of the Series Editor""; ""Preface to the Second Edition""; ""Preface to the First Edition""; ""Transmissible Spongiform Encephalopathies: The Prion Theory � Background and Basic Information""; ""Non-Virus Properties of the Scrapie Agent""; ""The Concept of Two Isoforms of the Prion Protein""; ""Basic Experiments Pro and Contra Prions""; ""The Search for a Nucleic Acid""; ""Structural Transitions of the Prion Protein as Basis for the Replication Mechanism"" , ""Infectious, Sporadic and Familial Etiology of Prion Diseases Based on the Prion Model""""Outlook""; ""Acknowledgment""; ""References""; ""Structural Biology of Prions""; ""The Primary Structure of the Prion Protein""; ""The Neurotoxic Model Peptide, PrP106�126""; ""Metal-Binding Domains of the Prion Protein""; ""Secondary Structure Analysis of the Prion Protein""; ""Tertiary Structure of the Normal Prion Protein (PrPC)""; ""Influence of Familial Mutations on the Structure of the Prion Protein""; ""Tertiary Structure of the Infectious Prion Protein (PrP TSE )"" , ""Deciphering the Structure of Infectious Prion Protein with Antibodies""""Prion Protein Folding Pathways and Their Conformational Properties""; ""Conclusion""; ""References""; ""Prion Strains and Species Barriers""; ""Prion Strains""; ""Molecular Basis of Prion Strains""; ""Species Barriers""; ""Subclinical Prion Infection""; ""Implications of Prion Disease vs. Prion Infection""; ""Re-Evaluating Prion Strains and Species Barriers""; ""Acknowledgement""; ""References""; ""Prions of Saccharomyces and Podospora""; ""Three Genetic Criteria for Prions""; ""[URE3] as a Prion of the Ure2 Protein"" , ""Structure of Ure2p""""Aggregation of Ure2p in vivo and in vitro""; ""[PSI] as a Prion of the Sup35 Protein""; ""Interaction with Other Proteins in the Cell and Influence of Chaperones""; ""Prion Variants""; ""Other Prions in Saccharomyces cerevisiae""; ""[Het-s], a Prion with a Normal Cellular Function""; ""Are in vitro Produced Filaments Infectious?""; ""Acknowledgement""; ""References""; ""Human Prion Diseases: Cause, Clinical and Diagnostic Aspects""; ""Creutzfeldt-Jakob Disease""; ""Sporadic CJD (spCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis"" , ""Iatrogenic (iCJD)""""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Variant (vCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Genetic (gCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Gerstmann-Str�ussler-Scheinker Syndrome (GSS)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Fatal Familial Insomnia""; ""Epidemiology and Cause""; ""Clinical""; ""Diagnosis""; ""Kuru""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""References"" , ""Epidemiology and Risk Factors of Transmissible Spongiform Encephalopathies in Man""
    Additional Edition: 3805576560
    Additional Edition: Print version Prions
    Language: English
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  • 4
    UID:
    (DE-602)edoccha_9958121349602883
    Format: 1 online resource (173 p.)
    Edition: 2nd ed.
    ISBN: 3-318-00622-X , 0-585-44056-5
    Series Statement: Contributions to microbiology, vol. 7
    Note: Description based upon print version of record. , ""Contents""; ""Preface""; ""Transmissible Spongiform Encephalopathies: The Viral Concept and an Application""; ""The Prion Theory: Background and Basic Information""; ""[URE3] and [PSI]: Prions of Saccharomyces cerevisiae""; ""Structural Biology of Prions""; ""Strain Variations and Species Barriers""; ""Resistance of Transmissible Spongiform Encephalopathy Agents to Decontamination""; ""Human Prion Diseases: Cause, Clinical and Diagnostic Aspects""; ""Epidemiology and Risk Factors of Transmissible Spongiform Encephalopathies in Man"" , ""Bovine Spongiform Encephalopathy and Its Relationship to the New Variant Form of Creutzfeldt-Jakob Disease""""Animal Transmissible Spongiform Encephalopathy: Clinical and Diagnostic Aspects""; ""The Challenge for the Public Health System""; ""Author Index""; ""Subject Index""; ""A""; ""B""; ""C""; ""D""; ""E""; ""F""; ""G""; ""I""; ""K""; ""M""; ""N""; ""P""; ""R""; ""S""; ""T""; ""U""; ""V"" , English
    Additional Edition: ISBN 3-8055-7124-0
    Language: English
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  • 5
    UID:
    (DE-602)edocfu_9958121349602883
    Format: 1 online resource (173 p.)
    Edition: 2nd ed.
    ISBN: 3-318-00622-X , 0-585-44056-5
    Series Statement: Contributions to microbiology, vol. 7
    Note: Description based upon print version of record. , ""Contents""; ""Preface""; ""Transmissible Spongiform Encephalopathies: The Viral Concept and an Application""; ""The Prion Theory: Background and Basic Information""; ""[URE3] and [PSI]: Prions of Saccharomyces cerevisiae""; ""Structural Biology of Prions""; ""Strain Variations and Species Barriers""; ""Resistance of Transmissible Spongiform Encephalopathy Agents to Decontamination""; ""Human Prion Diseases: Cause, Clinical and Diagnostic Aspects""; ""Epidemiology and Risk Factors of Transmissible Spongiform Encephalopathies in Man"" , ""Bovine Spongiform Encephalopathy and Its Relationship to the New Variant Form of Creutzfeldt-Jakob Disease""""Animal Transmissible Spongiform Encephalopathy: Clinical and Diagnostic Aspects""; ""The Challenge for the Public Health System""; ""Author Index""; ""Subject Index""; ""A""; ""B""; ""C""; ""D""; ""E""; ""F""; ""G""; ""I""; ""K""; ""M""; ""N""; ""P""; ""R""; ""S""; ""T""; ""U""; ""V"" , English
    Additional Edition: ISBN 3-8055-7124-0
    Language: English
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  • 6
    UID:
    (DE-602)edoccha_9958125388602883
    Format: 1 online resource (233 p.)
    Edition: 2nd, rev. and extended ed.
    ISBN: 3-318-01032-4
    Series Statement: Contributions to microbiology ; v. 11
    Content: This second, completely revised and extended edition of 〈i〉Prions: A Challenge for Science, Medicine and the Public Health System〈/i〉 is a comprehensive, up-to-date review of prions and prion-associated diseases. Leading scientists discuss the structure, molecular biology and origin of prions as well as strain variations and species barriers. Human prion diseases, prion inactivation and risks to public health are considered in detail. The new edition provides an update on basic findings of the last three years since publication of the previous edition and emphasizes practical aspects of fighting human and animal prion diseases. In addition, chapters on regulatory aspects of BSE and CJD as well as on veterinary measures have been included. A valuable single source of information on what is currently known about prions, this book will be of interest to any scientist or clinician who wants to keep up with the latest developments in this fast-moving field.
    Note: Description based upon print version of record. , ""Contents""; ""Dedication in Remembrance of Andreas Scheid (1941�2001)""; ""Note of the Series Editor""; ""Preface to the Second Edition""; ""Preface to the First Edition""; ""Transmissible Spongiform Encephalopathies: The Prion Theory � Background and Basic Information""; ""Non-Virus Properties of the Scrapie Agent""; ""The Concept of Two Isoforms of the Prion Protein""; ""Basic Experiments Pro and Contra Prions""; ""The Search for a Nucleic Acid""; ""Structural Transitions of the Prion Protein as Basis for the Replication Mechanism"" , ""Infectious, Sporadic and Familial Etiology of Prion Diseases Based on the Prion Model""""Outlook""; ""Acknowledgment""; ""References""; ""Structural Biology of Prions""; ""The Primary Structure of the Prion Protein""; ""The Neurotoxic Model Peptide, PrP106�126""; ""Metal-Binding Domains of the Prion Protein""; ""Secondary Structure Analysis of the Prion Protein""; ""Tertiary Structure of the Normal Prion Protein (PrPC)""; ""Influence of Familial Mutations on the Structure of the Prion Protein""; ""Tertiary Structure of the Infectious Prion Protein (PrP TSE )"" , ""Deciphering the Structure of Infectious Prion Protein with Antibodies""""Prion Protein Folding Pathways and Their Conformational Properties""; ""Conclusion""; ""References""; ""Prion Strains and Species Barriers""; ""Prion Strains""; ""Molecular Basis of Prion Strains""; ""Species Barriers""; ""Subclinical Prion Infection""; ""Implications of Prion Disease vs. Prion Infection""; ""Re-Evaluating Prion Strains and Species Barriers""; ""Acknowledgement""; ""References""; ""Prions of Saccharomyces and Podospora""; ""Three Genetic Criteria for Prions""; ""[URE3] as a Prion of the Ure2 Protein"" , ""Structure of Ure2p""""Aggregation of Ure2p in vivo and in vitro""; ""[PSI] as a Prion of the Sup35 Protein""; ""Interaction with Other Proteins in the Cell and Influence of Chaperones""; ""Prion Variants""; ""Other Prions in Saccharomyces cerevisiae""; ""[Het-s], a Prion with a Normal Cellular Function""; ""Are in vitro Produced Filaments Infectious?""; ""Acknowledgement""; ""References""; ""Human Prion Diseases: Cause, Clinical and Diagnostic Aspects""; ""Creutzfeldt-Jakob Disease""; ""Sporadic CJD (spCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis"" , ""Epidemiology and Risk Factors of Transmissible Spongiform Encephalopathies in Man"" , English
    Additional Edition: ISBN 1-4175-2256-9
    Additional Edition: ISBN 3-8055-7656-0
    Language: English
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  • 7
    UID:
    (DE-627)1805909223
    Format: 1 Online-Ressource (viii, 164 pages) , illustrations
    ISBN: 0585440565 , 9780585440569
    Series Statement: Contributions to microbiology vol. 7
    Content: In the past decades, the public has been forced to revise its perception of the apparent triumph of modern hygiene and medical microbiology over infectious diseases. Not only have older infections reemerged but new epidemics, like AIDS, have lead to public uncertainty. With the onset of the bovine spongiform encephalopathy epidemic in Great Britain, novel infectious agents came into the public spotlight, ones that do not cause classical inflammation but a slow and irreversible degeneration of the central nervous system. Sensational from a scientific point of view, these agents, called proteinaceous infectious organisms or prions, were shown to be self-replicating without nucleic acid sequences to encode genomic information.In this volume, leading scientists deal with the medical, scientific and public health questions that prion infections raise. Besides the 'prion or virus' discussion, the structures of prions and their molecular biological analysis as well as the questions of strain variations and species barrier are presented. The etiological, clinical and diagnostic aspects of transmissible spongiform encephalopathies are given special attention. The epidemiology of human and animal prion diseases, disease management and possibilities for inactivation of prions are discussed from a public health perspective. Directed at scientists, physicians and the public health sector, the monograph uses a multidisciplinary approach to present the latest findings on prion infection
    Note: Includes bibliographical references and indexes
    Additional Edition: 9783318006223
    Additional Edition: 331800622X
    Additional Edition: 3805571240
    Additional Edition: Erscheint auch als Druck-Ausgabe Prions Basel ; New York : Karger, ©2001
    Language: English
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  • 8
    UID:
    (DE-101)1287568254
    Format: Online-Ressource , online resource.
    ISSN: 1432-1246 , 1432-1246
    In: volume:83
    In: number:1
    In: day:22
    In: month:7
    In: year:2009
    In: pages:77-83
    In: date:1.2010
    In: International archives of occupational and environmental health, Berlin ; Heidelberg : Springer, 1930-, 83, Heft 1 (22.7.2009), 77-83, 1.2010, 1432-1246
    Language: English
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  • 9
    UID:
    (DE-604)BV013873015
    Format: graph. Darst.
    ISSN: 1438-4639
    Note: Inhalt u.a.: AIDS-Statistik in München
    In: International journal of hygiene and environmental health, Jena, 203 (2001),5/6, S. 393 - 399, 1438-4639
    Language: English
    Keywords: München ; Aids ; Statistik
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  • 10
    UID:
    (DE-604)BV048279150
    Format: 1 Online-Ressource (viii, 164 Seiten) , illustrations
    ISBN: 0585440565 , 331800622X , 9780585440569 , 9783318006223
    Series Statement: Contributions to microbiology vol. 7
    Content: In the past decades, the public has been forced to revise its perception of the apparent triumph of modern hygiene and medical microbiology over infectious diseases. Not only have older infections reemerged but new epidemics, like AIDS, have lead to public uncertainty. With the onset of the bovine spongiform encephalopathy epidemic in Great Britain, novel infectious agents came into the public spotlight, ones that do not cause classical inflammation but a slow and irreversible degeneration of the central nervous system. Sensational from a scientific point of view, these agents, called proteinaceous infectious organisms or prions, were shown to be self-replicating without nucleic acid sequences to encode genomic information.In this volume, leading scientists deal with the medical, scientific and public health questions that prion infections raise. Besides the 'prion or virus' discussion, the structures of prions and their molecular biological analysis as well as the questions of strain variations and species barrier are presented. The etiological, clinical and diagnostic aspects of transmissible spongiform encephalopathies are given special attention. The epidemiology of human and animal prion diseases, disease management and possibilities for inactivation of prions are discussed from a public health perspective. Directed at scientists, physicians and the public health sector, the monograph uses a multidisciplinary approach to present the latest findings on prion infection
    Additional Edition: Erscheint auch als Druck-Ausgabe Prions Basel ; New York : Karger, ©2001 ISBN 3805571240
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Prion ; Jakob-Creutzfeldt-Syndrom ; Prionkrankheit ; Spongiöse subakute Encephalopathie ; Aufsatzsammlung
    URL: Volltext  (kostenfrei)
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