Format:
1 Online-Ressource (14 Seiten)
ISSN:
1471-2407
Content:
Background: Acquired resistance to standard chemotherapy causes treatment failure in patients with metastatic bladder cancer. Overexpression of pro-survival Bcl-2 family proteins has been associated with a poor chemotherapeutic response, suggesting that Bcl-2-targeted therapy may be a feasible strategy in patients with these tumors. The small-molecule pan-Bcl-2 inhibitor (−)-gossypol (AT-101) is known to induce apoptotic cell death, but can also induce autophagy through release of the pro-autophagic BH3 only protein Beclin-1 from Bcl-2. ...
Note:
Systemvoraussetzungen: PDF-Reader
In:
BMC cancer, London : BioMed Central, 2001-, Band 15, Heft 224 (2015), 1471-2407
In:
volume:15
In:
year:2015
In:
number:224
Language:
English
DOI:
10.1186/s12885-015-1239-4
URN:
urn:nbn:de:hebis:30:3-373730