Format:
Online-Ressource (XII, 136 p. 15 illus., 3 illus. in color, digital)
ISBN:
9781461462170
Series Statement:
Advances in Experimental Medicine and Biology 785
Content:
This volume presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference “Crossroads between Innate and Adaptive Immunity” brought together leading international scientists and experts to address critical areas of Innate and Adaptive immunity something necessary for the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive immunity. The conference had limited participation and a scientific and social program that maximized scientific interchange through lecture presentations, poster sessions and informal discussions.
Note:
Description based upon print version of record
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Crossroads Between Innate and Adaptive Immunity IV; Preface; Acknowledgements; Contents; Contributors; 1: Vita-PAMPs: Signatures of Microbial Viability; 1.1 Introduction; 1.2 Live Versus Dead Pathogens: Role of Virulence Factors; 1.3 Microbial Viability Detection: Growth and Metabolism; 1.4 Detection of Microbial Viability Independently of Microbial Growth; 1.5 Features of Bacterial mRNAs; 1.6 Bacterial mRNA and Innate Immunity; 1.7 Vita-PAMPs and Adaptive Immunity; 1.8 PRRs That Orchestrate the Response to Bacterial Viability; 1.9 Conclusions; References
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2: Innate Lymphoid Cells in Immunity and Disease2.1 Introduction; 2.2 Phenotype of ILCs; 2.2.1 NK Cell Phenotype; 2.2.2 Ror g t-Dependent ILC Phenotype; 2.2.3 Type 2 ILC Phenotype; 2.3 Development of ILCs; 2.3.1 Inhibitor of DNA Binding 2 (Id2): An Early Common "Switch" for ILCs; 2.3.2 NK Cells Development; 2.3.3 Ror g t-Dependent ILCs Development; 2.3.4 Type 2 ILCs Development; 2.4 ILC Roles in the Host Organism; 2.4.1 NK Cells: Cytolytic Activity and Cytokine Production; 2.4.2 LTi Cells and Organogenesis of Lymphoid Structures
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2.4.3 Ror g t-Dependent ILCs: IL-17 and IL-22 Producers for Intestinal Homeostasis2.4.4 Type 2 ILCs: Protective Response Against Helminths; 2.4.5 Wound Healing; 2.4.6 Dysregulation of ILCs: Autoimmunity, Allergy, and Fibrosis; 2.5 Conclusion; References; 3: Tuning Cross-Presentation of Apoptotic T Cells in Immunopathology; 3.1 Introduction; 3.2 CD40 Ligand Expression on Apoptotic T Cells Abrogates Tolerance; 3.3 Apoptotic T Cells Are Source of Immunogenic Self-Antigens; 3.4 Relevance of Cross-Presentation of Apoptotic Epitopes in Clinical Setting; 3.5 Conclusion; References
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4: Regulation of Type 2 Immunity by Basophils4.1 Basophil Development and Homeostasis; 4.2 The Role of Basophils for Differentiation of Th2 Cells; 4.3 Basophils as Mediators of Allergic Responses; 4.4 Protective Immunity Against Ticks and Helminths; 4.5 Conclusion; References; 5: Crosstalk Between Adaptive and Innate Immune Cells Leads to High Quality Immune Protection at the Mucosal Borders; 5.1 Introduction; 5.2 Effector and Central Memory T Cells Form Distinct Subsets; 5.3 An Innate-Adaptive Crosstalk Drives the Selective Accumulation of Mucosal T EM
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5.3.1 Activation-Induced CD8 a a Rescues CD8 ab Primary Effector T Cells from AICD5.3.2 Activation-Induced CD8 a a Rescues CD8 a b Primary Effector T Cells from TICD; 5.3.3 Activation-Induced CD8 a a Rescues CD8 a b Secondary Effector T Cells from TICD; 5.4 Conclusion; 5.5 Future Prospective; References; 6: The Interaction Between Filarial Parasites and Human Monocyte/Macrophage Populations; 6.1 Background; 6.1.1 Lymphatic Filariasis; 6.1.2 Macrophages and Their Role in Inflammation; 6.2 Induction of AAM F s in Filarial Infections; 6.2.1 Animal Models; 6.2.2 Humans
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6.3 Implications in Clinical Settings
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Is Transcription the Dominant Force during Dynamic Changes in Gene Expression? -- MicroRNAs: Key Components of Immune Regulation -- KIR/HLA: Genetic Clues for a Role of NK cells in the Control of HIV -- Natural Killer cell Licensing during Viral Infection -- Bridging Innate NK cell Functions with Adaptive Immunity -- Control of Innate Immunity by Memory CD4 T cells -- Strategies and Implications for Prime-Boost Vaccinations to Generate Memory CD8 T Cells -- Blimp1: Driving Terminal Differentiation to a T -- A new Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis -- Impact of Differential Glycosylation on IgG Activity -- Murine Model of Chronic Respiratory Inflammation -- Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1 -- Influenza Vaccines: What do we Want and How can we Get it?..
Additional Edition:
ISBN 9781461462163
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-461-46216-3
Language:
English
Subjects:
Biology
DOI:
10.1007/978-1-4614-6217-0
URL:
Volltext
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