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  • Monograph/Item  (21)
  • GBV  (21)
Type of Material
Type of Publication
  • Monograph/Item  (21)
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Language
  • 1
    UID:
    (DE-627)338485074
    Format: 237 S , Ill., graph. Darst , 21 cm
    ISBN: 3936142114
    Note: Literaturangaben
    Language: German
    Keywords: HIV-Infektion ; Arzneimittelresistenz ; Aufsatzsammlung
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  • 2
    UID:
    (DE-627)027133052
    Format: 522 Seiten , Illustrationen
    Note: Mit 123 zum Teil farbigen Abbildungen und 48 Tabellen im Text , Literaturangaben
    Language: German
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  • 3
    UID:
    (DE-627)658543822
    Format: Online Ressource (3031 KB, 222 S.)
    Edition: 1. Aufl.
    Edition: Online-Ausg. 2011 Electronic reproduction; Available via World Wide Web
    ISBN: 3805576188 , 9783805576185
    Series Statement: Monographs in virology v. 24
    Content: Cytomegalovirus (CMV) infection causes severe diseases in immunocompromised patients. CMV-related morbidity is frequently linked to aberrant immune responses occurring locally within the respective tissues including immune-privileged sites such as the retina. There is growing evidence that CMV-related pathomechanisms differ profoundly as a function of cell type and differentiation state of the host cell. This book provides important new insights into CMV-related immunopathology, discusses molecular mechanisms involved in HCMV-mediated tissue injury, CMV latency and reactivation, and presents novel ideas and concepts to develop alternative antiviral drugs. As an important focus, the role of CMV-reactive T cells in protection, pathogenesis, diagnosis and therapy of HCMV infection is discussed. The contributions to this book are written by leading scientists and clinicians in the field of CMV who participated in the fourth international meeting on CMV-related immunopathology, held in Berlin, September 2002.
    Note: Includes bibliographical references and index , ""Contents""; ""Preface""; ""The Endothelium as a Mediator of CMV-Associated Immunopathology""; ""Effect of CMV Infection on Chronic Rejection of Kidney Transplants""; ""CMV and Atherosclerosis""; ""Human Cytomegalovirus in Immune Privileged Sites: HCMV Retinitis and the Role of NF-kB""; ""Transmission of Cytomegalovirus to Preterm Infants by Breast-Feeding""; ""Human Cytomegalovirus Escapes Cell-Mediated Immune Responses""; ""Counteraction of Interferon-Induced Antiviral Responses by Cytomegalovirus""; ""Mechanisms of Immunodominance in Human Cytomegalovirus Infection"" , ""HCMV Latency and Lytic Gene Regulation: A Question of Chromatin Structure?""""Taking Away the Replication License � HCMV and Its Impact on Cellular DNA Synthesis""; ""Interactions and Functions of Human Cytomegalovirus Tegument Proteins""; ""Measuring T-Cell Reactivity to Cytomegalovirus: State of the Art""; ""Measurement of CMV DNA Levels and CMV-Specific CD4 + Lymphocyte Counts in Patient Specimens: Requirements for Test Quality and Practicability in a Routine Diagnostic Service""; ""Manipulation of CMV-Specific Immune Responses following Stem Cell Transplantation"" , ""Fast Genotypic Identification and Estimation of Ganciclovir-Resistant Cytomegalovirus from Clinical Specimens""""Non-Nucleoside Inhibitors of HCMV Replication""; ""New Concepts for Inhibition of HCMV Reactivation and Replication""; ""CMV Vaccines to Prevent Congenital Infection""; ""Subject Index"" , Electronic reproduction; Available via World Wide Web
    Additional Edition: Erscheint auch als Druck-Ausgabe New Aspects of CMV-Related Immunopathology : 4th Symposium, Berlin, September 2002
    Language: English
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  • 4
    UID:
    (DE-627)773529195
    Format: Online-Ressource
    Note: Frankfurt am Main, Johann Wolfgang Goethe-Univ., Diss., 2011
    Language: German
    Keywords: Hochschulschrift
    URL: Volltext  (kostenfrei)
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  • 5
    UID:
    (DE-627)897288998
    Format: 1 Online-Ressource
    Note: Dissertation Frankfurt am Main, Johann Wolfgang Goethe-Universität 2010
    Additional Edition: Erscheint auch als Druck-Ausgabe Rothweiler, Florian, 1978- Überwindung der ABC-Transporter-vermittelten Chemoresistenz in Neuroblastomzellen
    Language: German
    Keywords: Hochschulschrift
    URL: Volltext  (kostenfrei)
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  • 6
    UID:
    (DE-627)32118999X
    Format: VIII, 164 S. , Ill., graph. Darst. , 25 cm
    ISBN: 3805571240
    Series Statement: Contributions to microbiology 7
    Note: Includes bibliographical references and indexes
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Prion ; Spongiöse subakute Encephalopathie ; Jakob-Creutzfeldt-Syndrom ; Prion ; Spongiöse subakute Encephalopathie ; Jakob-Creutzfeldt-Syndrom ; Aufsatzsammlung
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  • 7
    UID:
    (DE-627)88563859X
    Format: 1 Online-Ressource
    Note: Dissertation Frankfurt am Main, Johann Wolfgang Goethe-Universität 2017
    Language: German
    Keywords: Hochschulschrift
    URL: Volltext  (kostenfrei)
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  • 8
    UID:
    (DE-627)1805909223
    Format: 1 Online-Ressource (viii, 164 pages) , illustrations
    ISBN: 0585440565 , 9780585440569
    Series Statement: Contributions to microbiology vol. 7
    Content: In the past decades, the public has been forced to revise its perception of the apparent triumph of modern hygiene and medical microbiology over infectious diseases. Not only have older infections reemerged but new epidemics, like AIDS, have lead to public uncertainty. With the onset of the bovine spongiform encephalopathy epidemic in Great Britain, novel infectious agents came into the public spotlight, ones that do not cause classical inflammation but a slow and irreversible degeneration of the central nervous system. Sensational from a scientific point of view, these agents, called proteinaceous infectious organisms or prions, were shown to be self-replicating without nucleic acid sequences to encode genomic information.In this volume, leading scientists deal with the medical, scientific and public health questions that prion infections raise. Besides the 'prion or virus' discussion, the structures of prions and their molecular biological analysis as well as the questions of strain variations and species barrier are presented. The etiological, clinical and diagnostic aspects of transmissible spongiform encephalopathies are given special attention. The epidemiology of human and animal prion diseases, disease management and possibilities for inactivation of prions are discussed from a public health perspective. Directed at scientists, physicians and the public health sector, the monograph uses a multidisciplinary approach to present the latest findings on prion infection
    Note: Includes bibliographical references and indexes
    Additional Edition: 9783318006223
    Additional Edition: 331800622X
    Additional Edition: 3805571240
    Additional Edition: Erscheint auch als Druck-Ausgabe Prions Basel ; New York : Karger, ©2001
    Language: English
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  • 9
    UID:
    (DE-627)1780907745
    Format: 1 Online-Ressource
    Note: Dissertation Frankfurt am Main, Johann Wolfgang Goethe-Universität 2021
    Language: German
    Keywords: Hochschulschrift
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  • 10
    UID:
    (DE-627)80116012X
    Format: Online-Ressource (xi, 221 p) , ill
    Edition: 2nd, rev. and extended ed
    Edition: Online-Ausg.
    ISBN: 1417522569 , 9781417522569
    Series Statement: Contributions to microbiology v. 11
    Note: Includes bibliographical references and index , ""Contents""; ""Dedication in Remembrance of Andreas Scheid (1941�2001)""; ""Note of the Series Editor""; ""Preface to the Second Edition""; ""Preface to the First Edition""; ""Transmissible Spongiform Encephalopathies: The Prion Theory � Background and Basic Information""; ""Non-Virus Properties of the Scrapie Agent""; ""The Concept of Two Isoforms of the Prion Protein""; ""Basic Experiments Pro and Contra Prions""; ""The Search for a Nucleic Acid""; ""Structural Transitions of the Prion Protein as Basis for the Replication Mechanism"" , ""Infectious, Sporadic and Familial Etiology of Prion Diseases Based on the Prion Model""""Outlook""; ""Acknowledgment""; ""References""; ""Structural Biology of Prions""; ""The Primary Structure of the Prion Protein""; ""The Neurotoxic Model Peptide, PrP106�126""; ""Metal-Binding Domains of the Prion Protein""; ""Secondary Structure Analysis of the Prion Protein""; ""Tertiary Structure of the Normal Prion Protein (PrPC)""; ""Influence of Familial Mutations on the Structure of the Prion Protein""; ""Tertiary Structure of the Infectious Prion Protein (PrP TSE )"" , ""Deciphering the Structure of Infectious Prion Protein with Antibodies""""Prion Protein Folding Pathways and Their Conformational Properties""; ""Conclusion""; ""References""; ""Prion Strains and Species Barriers""; ""Prion Strains""; ""Molecular Basis of Prion Strains""; ""Species Barriers""; ""Subclinical Prion Infection""; ""Implications of Prion Disease vs. Prion Infection""; ""Re-Evaluating Prion Strains and Species Barriers""; ""Acknowledgement""; ""References""; ""Prions of Saccharomyces and Podospora""; ""Three Genetic Criteria for Prions""; ""[URE3] as a Prion of the Ure2 Protein"" , ""Structure of Ure2p""""Aggregation of Ure2p in vivo and in vitro""; ""[PSI] as a Prion of the Sup35 Protein""; ""Interaction with Other Proteins in the Cell and Influence of Chaperones""; ""Prion Variants""; ""Other Prions in Saccharomyces cerevisiae""; ""[Het-s], a Prion with a Normal Cellular Function""; ""Are in vitro Produced Filaments Infectious?""; ""Acknowledgement""; ""References""; ""Human Prion Diseases: Cause, Clinical and Diagnostic Aspects""; ""Creutzfeldt-Jakob Disease""; ""Sporadic CJD (spCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis"" , ""Iatrogenic (iCJD)""""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Variant (vCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Genetic (gCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Gerstmann-Str�ussler-Scheinker Syndrome (GSS)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Fatal Familial Insomnia""; ""Epidemiology and Cause""; ""Clinical""; ""Diagnosis""; ""Kuru""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""References"" , ""Epidemiology and Risk Factors of Transmissible Spongiform Encephalopathies in Man""
    Additional Edition: 3805576560
    Additional Edition: Print version Prions
    Language: English
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