UID:
almafu_9959328438702883
Format:
1 online resource
Edition:
First edition.
ISBN:
9781118940211
,
1118940210
,
9781118940204
,
1118940202
,
9781118940228
,
1118940229
Note:
1.2.4 The C-H Bond Functionalization Strategy1.2.5 The Building-Block Strategy; 1.2.6 The Collective Synthesis Strategy; 1.2.7 The Oligomerization Tactic; 1.3 The Expansion of the Field: Chemical Biology/Chemical Genetics; 1.3.1 Diversity-Oriented Synthesis (DOS); 1.3.2 Function-Oriented Synthesis (FOS); 1.3.3 Biology-Oriented Synthesis (BIOS); 1.3.4 Lead-Oriented Synthesis (LOS); 1.4 Addressing the Threats that Humans May Face in the Near Future; 1.4.1 A.G. Myers' Endeavor; 1.4.2 D.L. Boger's Endeavor; Acknowledgements; References.
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Intro; Title Page; Copyright Page; Contents; Contributors; Foreword; Preface; Introduction; 1 The Golden Age of the Total Synthesis of Natural Products: The Era as a Dominant Field; 2 1991-2000: A Contrasting Decade; 3 Total Synthesis in the Twenty-First Century; 4 The Challenges of the Efficiency in the Total Synthesis of Natural Products; 5 The Renaissance of Natural Products as Drug Candidates; 6 Recent Recognition of the Contribution of Natural Product-Based Drugs to Society; Acknowledgements; References; Chapter 1 Principles for Synthetic Efficiency and Expansion of the Field.
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1.1 Concepts for Efficiency in the Total Synthesis of Natural Products1.1.1 Ideal Synthesis; 1.1.2 Selectivity; 1.1.3 Green Synthesis; 1.1.4 Atom Economy; 1.1.5 E Factors; 1.1.6 Step Economy; 1.1.7 Pot Economy and PASE (Pot, Atom, and Step Economy); 1.1.8 Redox Economy; 1.1.9 Protecting-Group-Free Synthesis; 1.1.10 Multicomponent Reactions and One-Pot Reactions; 1.1.11 Scalability; 1.1.12 Convergent Synthesis; 1.2 Biomimetic Synthesis; 1.2.1 Basic Logic of Biosynthesis; 1.2.2 Tandem, Cascade, and Domino Reactions -- One-Pot Reactions; 1.2.3 Site and Stereoselective Reactions.
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Chapter 2 Selected Procedure-Economical Enantioselective Total Syntheses of Natural Products2.1 One-Step/One-Pot Enantioselective Total Synthesis of Natural Products/Drugs; 2.1.1 Robinson's One-Step Synthesis of Tropinone; 2.1.2 Hayashi's One-Pot Synthesis of (+)-ABT-341; 2.2 Two-Step/Two-Pot Enantioselective Total Synthesis of Natural Products; 2.2.1 Hayashi's Two-Pot Synthesis of (−)-Oseltamivir; 2.2.2 Ma's Two-Pot Synthesis of (−)-Oseltamivir; 2.2.3 Li's Two-Step Chemoenzymatic Total Synthesis of Aszonalenin; 2.2.4 Ishikawa's Two-Step Total Syntheses of (+)-WIN 64821 and (+)-Naseseazine B
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2.3 Three-Step/Three-Pot Enantioselective Total Synthesis of Natural Products2.3.1 Carreira's Three-Step Asymmetric Total Syntheses of (+)-Aszonalenin and (−)-Brevicompanine B; 2.3.2 Husson's Three-Step Asymmetric Total Synthesis of (−)-Sibirine; 2.3.3 MacMillan's Three-Step Asymmetric Total Synthesis of (+)-Frondosin B; 2.3.4 Hayashi's Three-Pot Total Synthesis of (−)-PGE1 Methyl Ester; 2.3.5 Porco's Three-Pot Total Synthesis of (−)-Hyperibone K; 2.4 Four-Step Enantioselective Total Synthesis of Natural Products; 2.4.1 Lawrence's Four-Step Total Synthesis of (−)-Angiopterlactone A
Additional Edition:
Print version: Efficiency in natural product total synthesis. Hoboken, NJ : John Wiley & Sons, 2018 ISBN 9781118605400
Language:
English
Keywords:
Electronic books.
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Electronic books.
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Electronic books.
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Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118940228
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118940228
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118940228
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